J
Judith Straimer
Researcher at Columbia University
Publications - 26
Citations - 2495
Judith Straimer is an academic researcher from Columbia University. The author has contributed to research in topics: Plasmodium falciparum & Artemisinin. The author has an hindex of 16, co-authored 23 publications receiving 1992 citations. Previous affiliations of Judith Straimer include Novartis Institute for Tropical Diseases & Novartis.
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Journal ArticleDOI
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
Judith Straimer,Nina F. Gnädig,Benoit Witkowski,Chanaki Amaratunga,Valentine Duru,Arba Pramundita Ramadani,Arba Pramundita Ramadani,Mélanie Dacheux,Nimol Khim,Lei Zhang,Stephen Lam,Philip D. Gregory,Fyodor D. Urnov,Odile Mercereau-Puijalon,Françoise Benoit-Vical,Françoise Benoit-Vical,Rick M. Fairhurst,Didier Menard,David A. Fidock +18 more
TL;DR: The data provide a conclusive rationale for worldwide K13-propeller sequencing to identify and eliminate artemisinin-resistant parasites and imperils efforts to reduce the global malaria burden.
Journal ArticleDOI
A Worldwide Map of Plasmodium Falciparum K13-Propeller Polymorphisms
Didier Menard,Nimol Khim,Johann Beghain,Ayola A. Adegnika,Ayola A. Adegnika,Mohammad Shafiul-Alam,Olukemi K. Amodu,Ghulam Rahim-Awab,Ghulam Rahim-Awab,Céline Barnadas,Céline Barnadas,Céline Barnadas,Antoine Berry,Yap Boum,Yap Boum,Maria Dorina Bustos,Jun Cao,Jun Hu Chen,Louis Collet,Liwang Cui,Garib Das Thakur,Alioune Dieye,Alioune Dieye,Djibrine Djalle,Monique A. Dorkenoo,Carole E. Eboumbou-Moukoko,Fe Espino,Thierry Fandeur,Maria de Fátima Ferreira-da-Cruz,Abebe A. Fola,Abebe A. Fola,Hans-Peter Fuehrer,Abdillahi Mohamed Hassan,Sócrates Herrera,Bouasy Hongvanthong,Sandrine Houzé,Maman Laminou Ibrahim,Mohammad Jahirul-Karim,Lubin Jiang,Shigeyuki Kano,Wasif Ali-Khan,Maniphone Khanthavong,Peter G. Kremsner,Marcus V. G. Lacerda,Rithea Leang,Mindy Leelawong,Mei Li,Khin Lin,Jean Baptiste Mazarati,Sandie Menard,Isabelle Morlais,Hypolite Muhindo-Mavoko,Hypolite Muhindo-Mavoko,Lise Musset,Kesara Na-Bangchang,Michael Nambozi,Karamoko Niaré,Harald Noedl,Jean-Bosco Ouédraogo,Dylan R. Pillai,Bruno Pradines,Bui Quang-Phuc,Michael Ramharter,Michael Ramharter,Milijaona Randrianarivelojosia,Jetsumon Sattabongkot,Abdiqani Sheikh-Omar,Kigbafori D. Silué,Sodiomon B. Sirima,Colin J. Sutherland,Din Syafruddin,Rachida Tahar,Lin Hua Tang,Offianan Andre Toure,Patrick Tshibangu-Wa-Tshibangu,Inès Vigan-Womas,Marian Warsame,Lyndes Wini,Sedigheh Zakeri,Saorin Kim,Rotha Eam,Laura Berne,Chanra Khean,Sophy Chy,Malen Ken,Kaknika Loch,Lydie Canier,Valentine Duru,Eric Legrand,Jean Christophe Barale,Barbara H. Stokes,Judith Straimer,Benoit Witkowski,David A. Fidock,Christophe Rogier,Pascal Ringwald,Frédéric Ariey,Odile Mercereau-Puijalon +97 more
TL;DR: In this article, the authors analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic and identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution.
Journal ArticleDOI
Targeting the cell stress response of plasmodium falciparum to overcome artemisinin resistance
Con Dogovski,Stanley C. Xie,Gaetan Burgio,Jess Bridgford,Sachel Mok,James M. McCaw,Kesinee Chotivanich,Shannon Kenny,Nina F. Gnädig,Judith Straimer,Zbynek Bozdech,David A. Fidock,Julie A. Simpson,Arjen M. Dondorp,Simon J. Foote,Nectarios Klonis,Leann Tilley +16 more
TL;DR: In this article, a detailed kinetic analysis of the drug responses of K13 wild-type and mutant isolates of Plasmodium falciparum sourced from a region in Cambodia (Pailin).
Journal ArticleDOI
Artemisinin Action and Resistance in Plasmodium falciparum.
TL;DR: This work describes recent progress made in defining the molecular basis of artemisinin resistance, which has identified a primary role for the P. falciparum K13 protein and suggests potential ways to overcome resistance.
Journal ArticleDOI
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
M. Isabel Veiga,M. Isabel Veiga,Satish K. Dhingra,Philipp P. Henrich,Judith Straimer,Nina F. Gnädig,Anne-Catrin Uhlemann,Rowena E. Martin,Adele M. Lehane,Adele M. Lehane,David A. Fidock +10 more
TL;DR: Zinc-finger nucleases are used to genetically modify the multidrug resistance-1 transporter PfMDR1 at amino acids 86 and 184, and it is demonstrated that the widely prevalent N86Y mutation augments resistance to the ACT partner drug amodiaquine and the former first-line agent chloroquine.