F
Frank E. Speizer
Researcher at Brigham and Women's Hospital
Publications - 641
Citations - 140522
Frank E. Speizer is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Relative risk & Risk factor. The author has an hindex of 193, co-authored 636 publications receiving 135891 citations. Previous affiliations of Frank E. Speizer include Medical Research Council & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
A functional mutation in the terminal exon of elastin in severe, early onset chronic obstructive pulmonary disease: Am J Respir Cell Mol Biol 2005;33:355–62
C.M. Kelleher,Edwin K. Silverman,T. Broekelmann,Augusto A. Litonjua,M. Hernandez,Jody S. Sylvia,Joan M. Stoler,John J. Reilly,Harold A. Chapman,Frank E. Speizer,Scott T. Weiss,R.P. Mecham,Benjamin A. Raby +12 more
TL;DR: It is suggested that the G773D variant of human elastin confers structural and functional consequences relevant to the pathogenesis of COPD.
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Asthma and Persistent Wheeze in the Harvard Six Cities Study
TL;DR: The Harvard Six Cities Study provides some insight into the role of ambient pollutants in the exacerbation of symptoms in these diseases, and in general, new onset asthma does not appear to be related to ambient particulate levels.
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The Health Effects of Automobile Exhaust. VI. Relationship of Respiratory Symptoms and Pulmonary Function in Tunnel and Turnpike Workers
TL;DR: Smoking was strongly related to respiratory symptoms of cough and phlegm production, but not to wheezing, breathlessness, bronchial asthma, or frequent chest colds, and no effect could be seen between high automobile exhaust exposure as measured by a variety of parameters and all of the above respiratory symptoms and illnesses.
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Asthma history, job type and job changes among US nurses
Orianne Dumas,Orianne Dumas,Raphaëlle Varraso,Raphaëlle Varraso,Jan Paul Zock,Paul K. Henneberger,Frank E. Speizer,Aleta Wiley,Nicole Le Moual,Nicole Le Moual,Carlos A. Camargo,Carlos A. Camargo +11 more
TL;DR: For example, the authors found that nurses with a baseline history of asthma were more likely to move to jobs with lower exposure to disinfectants (HR 1.13 (1.07 to 1.18), especially among those with more severe asthma (HR for mild persistent: 1.26; moderate persistent 1.50, compared with intermittent asthma, p trend: 0.004).
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Maximal and partial expiratory flow rates in a population sample of 10- to 11-yr-old schoolchildren. Effect of volume history and relation to asthma and maternal smoking.
George T. O'Connor,David Sparrow,Deborah Demolles,Douglas W. Dockery,Mark Raizenne,Martha E. Fay,Roland H. Ingram,Frank E. Speizer +7 more
TL;DR: The results suggest that the measurement of volume history effects offers no benefits for epidemiological studies of childhood respiratory disease whereas spirometric indices such as the FEF(25-75)/FVC ratio are quite sensitive to the effects of asthma and environmental tobacco smoke exposure on the airways.