F
Franz Oesch
Researcher at University of Mainz
Publications - 580
Citations - 22320
Franz Oesch is an academic researcher from University of Mainz. The author has contributed to research in topics: Epoxide hydrolase & Microsomal epoxide hydrolase. The author has an hindex of 76, co-authored 578 publications receiving 21684 citations. Previous affiliations of Franz Oesch include University of Basel & National Institutes of Health.
Papers
More filters
Book ChapterDOI
Use of Mechanistic Information for Adequate Metabolic Design of Genotoxicity Studies and Toxicological Interactions of Drugs and Environmental Chemicals
Franz Oesch,F. Fähndrich,F. Fähndrich,Hansruedi Glatt,Barbara Oesch-Bartlomowicz,Karl-Ludwig Platt,Dietmar Utesch +6 more
TL;DR: Microorganisms as well as mammalian cells used for mutagenicity investigations have little or no activities for metabolism of premutagens and precarcinogens, i.e. of compounds ultimately leading to mutations and cancer but first requiring metabolic activation, and an exogenous activating system is added.
Journal ArticleDOI
The Stereoisomeric Fjord-Region Benzo[c]phenanthrene-3,4-Dihydrodiol 1,2-Oxides Malignantly Transform Rat Liver Epithelial Cells
TL;DR: Experimental evidence is presented that proliferation plays a central role in liver cell transformation mediated by polycyclic aromatic hydrocarbons and the fjord-region dihydrodiol epoxides of benzo[c]phenanthrene are able to efficiently transform rat liver cells.
Book ChapterDOI
Investigating the role of the microsomal epoxide hydrolase membrane topology and its implication for drug metabolism pathways.
TL;DR: It is demonstrated that the amino-terminal twenty amino acid residues of this protein serve as its single membrane anchor signal sequence and that the function of this sequence can be also supplied by a cytochrome P450 (CYP2B1) anchor signal sequences.
Book ChapterDOI
Epoxide hydratase and its membrane environment
TL;DR: Experiments with ferritin labelled antibodies showed that epoxide hydr atase was accessible from outside the membrane, and that hydratase in outer nuclear membranes was immunologically cross reactive with that of endoplasmic reticulum.
Journal ArticleDOI
Morphological, Biochemical, and Molecular Biological Characterization of a Rat Rhabdomyosarcoma Cell Line during Differentiation Induction In Vitro
TL;DR: BA-HAN-1C is a clonal rat rhabdomyosarcoma cell line consisting of proliferating mononuclear tumor cells, some of which spontaneously fuse to form terminally differentiated postmitotic myotubelike giant cells which resulted in an inhibition of proliferation and a marked increase in cellular differentiation.