F
Franz Oesch
Researcher at University of Mainz
Publications - 580
Citations - 22320
Franz Oesch is an academic researcher from University of Mainz. The author has contributed to research in topics: Epoxide hydrolase & Microsomal epoxide hydrolase. The author has an hindex of 76, co-authored 578 publications receiving 21684 citations. Previous affiliations of Franz Oesch include University of Basel & National Institutes of Health.
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Hepatocyte-mediated, but not S9-mediated mutagenicity correlates with the carcinogenicity of methylbenz[a]anthracenes
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Importance of knowledge on drug metabolism for the safe use of drugs in humans
TL;DR: Th e author thanks ECNIS (Environmental Cancer, Nutrition and Individual Susceptibility), a network of excellence operating within the European Union 6th Framework Program, Priority 5: Food Quality and Safety for financial support.
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Reduction of glutathione content by 12-O-tetradecanoylphorbol-13-acetate in confluent, but not in sparse cultures of human diploid fibroblasts.
TL;DR: It was shown that TPA treatment of sparse cultures grown in the presence of immobilized plasma membrane proteins also resulted in a 70% reduction of glutathione content, which agrees with the postulated involvement of redox reactions in tumor promotion and point to a central role of cell-cell contacts in the regulation of biochemical events which are critical in tumorigenesis.
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Conjugation reactions of polyaromatic quinones to mono- and bisglutathionyl adducts: Direct analysis by fast atom bombardment mass spectrometry
TL;DR: The conjugation products of several reactive quinones with glutathione have been identified by fast atom bombardment mass spectrometry by providing the direct detection and differentiation of the formation of mono- and bisglutathionyl adducts between regioisomeric quinone substrates.
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Toxicological Implications of Enzymatic Control of Reactive Metabolites
Franz Oesch,Johannes Doehmer,Thomas Friedberg,Hansruedi Glatt,Barbara Oesch-Bartlomowicz,Karl-Ludwig Platt,Pablo Steinberg,Dietmar Utesch,Helmut Thomas +8 more
TL;DR: The efficiency of these enzyme systems in preventing reactive metabolite-mediated toxicity is directed by their subcellular compartmentalization and isoenzymic multiplier.