F
Franz Oesch
Researcher at University of Mainz
Publications - 580
Citations - 22320
Franz Oesch is an academic researcher from University of Mainz. The author has contributed to research in topics: Epoxide hydrolase & Microsomal epoxide hydrolase. The author has an hindex of 76, co-authored 578 publications receiving 21684 citations. Previous affiliations of Franz Oesch include University of Basel & National Institutes of Health.
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Journal ArticleDOI
Differential effects of fluvoxamine and other antidepressants on the biotransformation of melatonin
Sebastian Härtter,Ximing Wang,Harald Weigmann,Thomas Friedberg,Michael Arand,Franz Oesch,Christoph Hiemke +6 more
TL;DR: Fluvoxamine is a potent inhibitor of melatonin degradation and might be used as an enhancer ofmelatonin, which might offer new therapeutic possibilities of fluvoxamines.
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Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human.
Helena Carmo,Jan G. Hengstler,D. de Boer,M. Ringel,Fernando Remião,Félix Carvalho,Eduarda Fernandes,Lesseps A. dos Reys,Franz Oesch,Maria de Lourdes Bastos +9 more
TL;DR: Comparing the toxic effects of 2C-B between hepatocytes of the six examined species the authors observed only minor interspecies differences, however, large inter-individual differences in susceptibility of hepatocytes from three human donors were observed.
Search for cell culture systems with diverse xenobiotic-metabolizing activities and their use in toxicological studies.
TL;DR: Screening 18 cell lines for monooxygenase, cytochrome P-450 reductase, epoxide hydrolase, glutathione transferase, and UDP-glucuronosyl transferase activities appears ideal in the identification of critical xenobiotic-metabolizing enzymes for a given mutagen.
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Contact inhibition of growth of human diploid fibroblasts by immobilized plasma membrane glycoproteins.
R.J. Wieser,Franz Oesch +1 more
TL;DR: Results show that cell-cell contacts via plasma membrane glycoproteins carrying terminal galactose residues are important for the regulation of the proliferation of cultured human fibroblasts and presumably of the accelerated synthesis of collagen type III.
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c-erbB-2 expression in small-cell lung cancer is associated with poor prognosis.
Patrick Micke,Jan G. Hengstler,Roser Ros,Fernando Bittinger,Tsegay Metz,Susanne Gebhard,Kai Michael Beeh,Franz Oesch,Roland Buhl +8 more
TL;DR: C‐erbB‐2 is expressed in more than 10% of SCLC and is an independent prognostic factor of survival, and the effect of c‐erb B‐2 expression seems to become more important in advanced stages of the disease.