F
Franz Oesch
Researcher at University of Mainz
Publications - 580
Citations - 22320
Franz Oesch is an academic researcher from University of Mainz. The author has contributed to research in topics: Epoxide hydrolase & Microsomal epoxide hydrolase. The author has an hindex of 76, co-authored 578 publications receiving 21684 citations. Previous affiliations of Franz Oesch include University of Basel & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Isoenzyme-specific phosphorylation of cytochromes P-450 and other drug metabolizing enzymes.
TL;DR: A series of fourteen cytochrome P-450 isoenzymes was treated with three different protein kinases and found to divide into isoenZymes phosphorylated by both the cyclic AMP-dependent kinase and the calcium-phospholipid-dependent Kinase.
Journal Article
DNA strand breaks and DNA cross-links in peripheral mononuclear blood cells of ovarian cancer patients during chemotherapy with cyclophosphamide/carboplatin
TL;DR: Monitoring DNA single-strand breaks in the peripheral mononuclear blood cells of patients can help to evaluate the efficiencies of the cancer treatment as a composite of individual differences in resorption, metabolic activation and detoxification, and possibly some constitutional aspects of drug resistance to cyclophosphamide/cisplatin and probably to several other alkylating antineoplastic drugs.
Journal ArticleDOI
Identification of human cytochromes P-450 analogous to forms induced by phenobarbital and 3-methylcholanthrene in the rat.
TL;DR: Antibody inhibition of microsomal 7-ethoxycoumarin and 7-ETHoxyresorufin metabolism demonstrated a degree of conservation of substrate specificity related to specific P-450 isoenzymes between the species.
Journal ArticleDOI
Glutathione, GlutathioneS-Transferase α and π, and Aldehyde Dehydrogenase Content in Relationship to Drug Resistance in Ovarian Cancer
Berno Tanner,Jan G. Hengstler,Britta Dietrich,Michael Henrich,Pablo Steinberg,W. Weikel,Rolf Meinert,Bernd Kaina,Franz Oesch,Paul Georg Knapstein +9 more
TL;DR: Glutathione content was associated with progression of ovarian carcinomas but neither glutathione nor glutATHione S -transferases α and π or aldehyde dehydrogenase were independent factors of resistance to cyclophosphamide/carboplatin.
Book ChapterDOI
Individual differences in DNA repair capacities in man.
TL;DR: The investigation of the DNA repair of methylnitrosourea-induced lesions showed significant interindividual differences in the adaptive response triggered by repeated exposure to the carcinogen, whereas the interindividual variations after single doses were low.