F
Franz Oesch
Researcher at University of Mainz
Publications - 580
Citations - 22320
Franz Oesch is an academic researcher from University of Mainz. The author has contributed to research in topics: Epoxide hydrolase & Microsomal epoxide hydrolase. The author has an hindex of 76, co-authored 578 publications receiving 21684 citations. Previous affiliations of Franz Oesch include University of Basel & National Institutes of Health.
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Book ChapterDOI
Monitoring Sodium Dodecyl Sulfate Contamination
TL;DR: The chapter presents the development of a simple yet sensitive method that is based on formation of the ion pair SDS and methylene blue and subsequent extraction of this complex with chloroform, which is extremely useful for monitoring the presence of minute amounts of the detergent in samples of interest.
Journal ArticleDOI
Influence of CYP2D6 polymorphism on 3,4-methylenedioxymethamphetamine (“ecstasy”) cytotoxicity
Helena Carmo,M. Brulport,Matthias Hermes,Franz Oesch,Renata Silva,Luísa M. Ferreira,Paula S. Branco,D. de Boer,Fernando Remião,Félix Carvalho,Michael R. Schön,Niels Krebsfaenger,Johannes Doehmer,Maria de Lourdes Bastos,Jan G. Hengstler +14 more
TL;DR: In this paper, the authors investigated whether CYP2D6 or its variant alleles as well as CYP3A4 influence the susceptibility to 3,4-methylenedioxymethamphetamine.
Journal ArticleDOI
Induction and suppression of cytochromes P-450 in rat tissues
TL;DR: Data show that P-450 MC, , or structurally similar proteins, are the most abundant in the rat liver yet are minor forms in the kidney and lungs, which could possibly be accounted for by the reactivity of anti-MC, with P- 450 MC2 (Wolf et al., 1984~).
Journal ArticleDOI
The Effect of Indobufen on the Activities of Selected Rat Liver Phase I and Phase II Drug Metabolizing Enzymes, Peroxisomal β-oxidation and Hepatic Glutathione Status
TL;DR: The results obtained in this study are indicative of the action of indobufen as a weak peroxisome proliferator in male rat liver, and suggest a slight but toxicologically insignificant inhibitory action of this drug on microsomal cytochrome P450‐dependent enzyme activities.
Journal ArticleDOI
Purity of triatiated polycyclic aromatic hydrocarbons: Identification of [G-3H]-5,6-dihydrodibenz[a, h]anthracene as the major radioactive component in commercial [G-3H]dibenz[a, h]anthracene
TL;DR: The major radioactive component of a commercial sample of [G-3H]-5,6-dihydrodibenz[a, h]anthracene was not this compound but was identified as a compound that could be efficiently transformed by dehydrogenation into the tritiated parent hydrocarbon.