F
Franz Oesch
Researcher at University of Mainz
Publications - 580
Citations - 22320
Franz Oesch is an academic researcher from University of Mainz. The author has contributed to research in topics: Epoxide hydrolase & Microsomal epoxide hydrolase. The author has an hindex of 76, co-authored 578 publications receiving 21684 citations. Previous affiliations of Franz Oesch include University of Basel & National Institutes of Health.
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Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons.
David H. Phillips,Alan Hewer,Albrecht Seidel,Thomas Steinbrecher,Rainer Schrode,Franz Oesch,Hansruedi Glatt +6 more
TL;DR: The potent mutagenicity of the fjord region diol-epoxides appears to be due to the high frequency with which they form DNA adducts in V79 cells, rather than to formation ofAdducts with greater mutagenic potential.
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A new assay for glutathione S-transferase using [3H]-benzo(a)pyrene 4,5-oxide as substrate. Inducibility by various chemicals in different rat tissues compared to that of aryl hydrocarbon hydroxylase and epoxide hydratase.
TL;DR: The results constitute an additional argument in favor of a minor role of possible changes in the concentration of this enzyme in the regulation of polycyclic aromatic hydrocarbons elimination.
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Characteristics of polychlorinated biphenyl (PCB) atropisomers
TL;DR: In this article, the rotational stability of the enantiomer pairs of 3 PCBs with axial chirality has been analyzed and shown to be stable to racemization at room temperature.
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Recombinant expression of human microsomal epoxide hydrolase protects V79 Chinese hamster cells from styrene oxide- but not from ethylene oxide-induced DNA strand breaks.
TL;DR: Results clearly show that the metabolism of styrene 7,8‐oxide by hmEH in 92hmEH‐V79 cells was responsible for the protection against styrene 6,7‐oxide genotoxicity, and selectivity of the protective effect on epoxidegenotoxicity appears to be an important factor that must be taken into account for the prediction of the genotoxic risk of epoxides themselves or compounds that can be metabolically activated to epoxide.
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Dissociation between changes in cyclic AMP and subsequent induction of TH in the rat superior cervical ganglion and adrenal medulla
U. Otten,Franz Oesch,H. Thoenen +2 more
TL;DR: It is concluded that either cyclic AMP is not involved in trans-synaptic induction of TH or that changes in a small pool are essential and are overshadowed by a much larger pool of cyclicAMP not reacting in the same way.