Franz Oesch

TL;DR: Activating ‘cross-talk’ with MAPK signaling as a novel principle of AhR action is established, which is apparently independent of the AhR's function as a DNA-binding transcriptional activator.

TL;DR: The findings indicate that when microsomes from untreated and phenobarbital-treated mice were used the main contributors to the mutagenicity were simple epoxides (or compounds arising non-enzymically from them) and the activation of dihydrodiols must, however, contribute to a significant extent when microSomes from methylcholanthrene-treated dogs were used.

TL;DR: The isolation of the gene and cDNA for the A. niger EH by use of inverse PCR yielded a fully active EH with similar characteristics to the fungal enzyme and offers a versatile tool for the bio-organic chemist for the chiral synthesis of a variety of fine chemicals.

TL;DR: This review attempts to summarize the information available in the open scientific literature on XME in the skin of human, rat, mouse, guinea pig, and pig as well as human primary skin cells, human cell lines, and reconstructed human skin models to suggest some models may tentatively be considered to approximate reasonable closeness to human skin.

TL;DR: Benzene and 13 potential metabolites were investigated for genotoxicity in Salmonella typhimurium and V79 Chinese hamster cells and only the trans-1,2-dihydrodiol proved mutagenic in this strain, while the anti-diol epoxide was more potent than the syn-diastereomer.