Frederik-Jan van Schooten

TL;DR: Application of breath biomarker measurement in a standardised manner will provide comparable results, thereby facilitating the potential use of these biomarkers in clinical practice, and highlighting future research priorities in the field.

TL;DR: In this article, particular emphasis is given to molecular alterations in the heart, which is the preferential target for the formation of DNA adducts in smokers, and in human aorta, where an extensive molecular epidemiology project is documenting the systematic presence ofAdducts to the nuclear DNA of smooth muscle cells from atherosclerotic lesions, and their significant correlation with known atherogenic risk factors.

TL;DR: It is concluded that metabolomics of VOCs in exhaled breath was possible in a reproducible way and was able to discriminate not only between CF patients and controls but also betweenCF patients with or without Pseudomonas colonization.

TL;DR: Dose-response meta-analyses showed a BC risk plateau for smoking intensity and indicate that even after long-term smoking cessation, an elevated risk of bladder cancer remains.

TL;DR: In respiratory medicine, expired volatile organic compounds (VOCs) are associated with inflammatory, oxidative, microbial, and neoplastic processes, which has promoted the development and clinical application of non-invasive metabolomics in exhaled air (breathomics).