T
Tara C. Mills
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 11
Citations - 1064
Tara C. Mills is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 9, co-authored 10 publications receiving 847 citations.
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Journal ArticleDOI
Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study
Emma E. Davenport,Katie L. Burnham,Jayachandran Radhakrishnan,Peter Humburg,Paula Hutton,Tara C. Mills,Anna Rautanen,Anthony C. Gordon,Christopher S. Garrard,Adrian V. S. Hill,Charles J. Hinds,Julian C. Knight +11 more
TL;DR: The integrated genomics approach advances understanding of heterogeneity in sepsis by defining subgroups of patients with different immune response states and prognoses, as well as revealing the role of underlying genetic variation.
Journal ArticleDOI
Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study
Anna Rautanen,Tara C. Mills,Anthony C. Gordon,Paula Hutton,Michael Steffens,Rosamond A. Nuamah,Jean-Daniel Chiche,Tom Parks,Stephen J Chapman,Emma E. Davenport,Katherine S. Elliott,Julian Bion,Peter Lichtner,Thomas Meitinger,Thomas F. Wienker,Mark J. Caulfield,Charles A. Mein,Frank Bloos,Ilona Bobek,Paolo Cotogni,Vladimír Šrámek,Silver Sarapuu,Makbule Kobilay,V. Marco Ranieri,Jordi Rello,Gonzalo Sirgo,Yoram Weiss,Stefan Russwurm,E Marion Schneider,Konrad Reinhart,Paul A. H. Holloway,Julian C. Knight,Christopher S. Garrard,James A. Russell,Keith R. Walley,Frank Stüber,Adrian V. S. Hill,Charles J. Hinds +37 more
TL;DR: Common variants in the FER gene and associated molecular pathways are potential novel targets for therapy or prevention and candidates for the development of biomarkers for risk stratification.
Journal ArticleDOI
Leprosy and the adaptation of human toll-like receptor 1.
Sunny H. Wong,Sailesh Gochhait,Dheeraj Malhotra,Fredrik Pettersson,Yik Y. Teo,Chiea Chuen Khor,Chiea Chuen Khor,Anna Rautanen,Stephen J Chapman,Tara C. Mills,Amit Kumar Srivastava,Aleksey A Rudko,Maxim B. Freidin,Maxim B. Freidin,V. P. Puzyrev,Shafat Ali,Shweta Aggarwal,Rupali Chopra,Belum Siva Nagi Reddy,Vijay K Garg,S. Roy,Sarah Meisner,Sunil K. Hazra,Bibhuti Saha,Sian Floyd,Brendan J. Keating,Cecilia Kim,Benjamin P. Fairfax,Julian C. Knight,Philip C. Hill,Richard A. Adegbola,Hakon Hakonarson,Paul E. M. Fine,Ramasamy Pitchappan,Rameshwar N. K. Bamezai,Adrian V. S. Hill,Fredrik O. Vannberg +36 more
TL;DR: An association analysis of more than 1,500 individuals from different case-control and family studies observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases.
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CISH and Susceptibility to Infectious Diseases
Chiea Chuen Khor,Fredrik O. Vannberg,Stephen J Chapman,Hailong Guo,Sunny H. Wong,Andrew Walley,Damjan Vukcevic,Anna Rautanen,Tara C. Mills,Chang K-C.,Kam K-M.,Amelia C. Crampin,Bagrey Ngwira,Leung C-C.,Tam C-M.,Chan C-Y.,Sung Jjy.,Yew W-W.,Toh K-Y.,Tay Skh.,Dominic P. Kwiatkowski,Christian Lienhardt,Hien T-T.,N P Day,N Peshu,Kevin Marsh,Kathryn Maitland,J A Scott,Thomas N. Williams,James A. Berkley,Sian Floyd,Tang Nls.,Fine Pem.,Goh Dlm.,Hill Avs. +34 more
TL;DR: Variants of CISH are associated with susceptibility to diseases caused by diverse infectious pathogens, suggesting that negative regulators of cytokine signaling have a role in immunity against various infectious diseases.
Journal ArticleDOI
IFITM3 and Susceptibility to Respiratory Viral Infections in the Community
Tara C. Mills,Anna Rautanen,Katherine S. Elliott,Tom Parks,Vivek Naranbhai,Margareta Ieven,Christopher C Butler,Paul Little,Theo J M Verheij,Christopher S. Garrard,Charles J. Hinds,Herman Goossens,Stephen J Chapman,Adrian V. S. Hill +13 more
TL;DR: Evidence is found of an association between rs12252 rare allele homozygotes and susceptibility to mild influenza (in patients attending primary care) but could not confirm a previously reported association between this single-nucleotide polymorphism and susceptible to severe H1N1 infection.