G
G Venkat Rao
Researcher at Baylor College of Medicine
Publications - 39
Citations - 970
G Venkat Rao is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Pancreatitis & Odds ratio. The author has an hindex of 14, co-authored 37 publications receiving 738 citations.
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Journal ArticleDOI
Variants in CPA1 are strongly associated with early onset chronic pancreatitis
Heiko Witt,Sebastian Beer,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Giriraj R. Chandak,Atsushi Masamune,Melinda Bence,Richárd Szmola,Richárd Szmola,Grzegorz Oracz,Milan Macek,Eesh Bhatia,Sandra Steigenberger,Denise Lasher,Florence Bühler,Catherine Delaporte,Johanna Tebbing,Maren Ludwig,Claudia Pilsak,Karolin Saum,Peter Bugert,Emmanuelle Masson,Emmanuelle Masson,Sumit Paliwal,Seema Bhaskar,Agnieszka Sobczynska-Tomaszewska,Daniel Bak,Ivan Balascak,Gourdas Choudhuri,D. Nageshwar Reddy,G Venkat Rao,Varghese Thomas,Kiyoshi Kume,Eriko Nakano,Yoichi Kakuta,Tooru Shimosegawa,Lukasz Durko,András Szabó,Andrea Schnúr,Andrea Schnúr,Péter Hegyi,Zoltán Rakonczay,Roland H. Pfützer,Alexander Schneider,David A. Groneberg,Markus Braun,Hartmut Schmidt,Ulrike Witt,Helmut Friess,Hana Algül,Olfert Landt,Markus Schuelke,Renate Krüger,Bertram Wiedenmann,Frank Schmidt,Klaus Peter Zimmer,Peter Kovacs,Michael Stumvoll,Matthias Blüher,Thomas Müller,Andreas R. Janecke,Niels Teich,Robert Grützmann,Hans Ulrich Schulz,Joachim Mössner,Volker Keim,Matthias Löhr,Claude Férec,Claude Férec,Miklós Sahin-Tóth +70 more
TL;DR: The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
Journal ArticleDOI
Pancreatic stellate cell: Pandora's box for pancreatic disease biology.
Ratnakar R. Bynigeri,Aparna Jakkampudi,Ramaiah Jangala,C. Subramanyam,Mitnala Sasikala,G Venkat Rao,D. Nageshwar Reddy,Rupjyoti Talukdar +7 more
TL;DR: It is shown that PSCs are involved in significant crosstalk between the pancreatic cancer cells and the cancer stroma, which result in tumour progression, metastasis, tumour hypoxia, immune evasion and drug resistance.
Journal ArticleDOI
Altered intestinal microbiota in patients with chronic pancreatitis: implications in diabetes and metabolic abnormalities.
Sai Manasa Jandhyala,A. Madhulika,G. Deepika,G Venkat Rao,D. Nageshwar Reddy,C. Subramanyam,Mitnala Sasikala,Rupjyoti Talukdar +7 more
TL;DR: The taxonomic and functional alterations in intestinal microbiota in 30 well-characterised patients with CP and 10 healthy controls were evaluated, finding significant differences in richness and alpha diversity between the groups.
Journal ArticleDOI
Comprehensive screening of chymotrypsin C ( CTRC ) gene in tropical calcific pancreatitis identifies novel variants
Sumit Paliwal,Seema Bhaskar,K. Radha Mani,D. Nageshwar Reddy,G Venkat Rao,Shivaram Prasad Singh,Varghese Thomas,Giriraj R. Chandak +7 more
TL;DR: This study on a large cohort of TCP patients provides evidence of allelic heterogeneity and confirms that CTRC variants play a significant role in its pathogenesis.
Journal ArticleDOI
Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis
TL;DR: A two hit model is proposed to explain the sequence of events in the pathogenesis of TCP, a severe form of chronic pancreatitis unique to developing countries.