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Volker Keim
Researcher at Leipzig University
Publications - 130
Citations - 5346
Volker Keim is an academic researcher from Leipzig University. The author has contributed to research in topics: Pancreatitis & Trypsinogen. The author has an hindex of 33, co-authored 130 publications receiving 4722 citations. Previous affiliations of Volker Keim include French Institute of Health and Medical Research.
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Journal ArticleDOI
Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis
Thomas Karlas,David Petroff,Magali Sasso,Jian-Gao Fan,Yu Qiang Mi,Victor de Ledinghen,Manoj Kumar,Monica Lupsor-Platon,Kwang Hyub Han,Ana Carolina Cardoso,Giovanna Ferraioli,Wah-Kheong Chan,Vincent Wai-Sun Wong,Robert P. Myers,Kazuaki Chayama,Mireen Friedrich-Rust,Michel Beaugrand,Feng Shen,Jean Baptiste Hiriart,Shiv Kumar Sarin,Radu Badea,Kyu Sik Jung,Patrick Marcellin,Carlo Filice,Sanjiv Mahadeva,Grace Lai-Hung Wong,Pam Crotty,Keiichi Masaki,Joerg Bojunga,Pierre Bedossa,Volker Keim,Johannes Wiegand +31 more
TL;DR: CAP provides a standardized non-invasive measure of hepatic steatosis and factors such as the underlying disease, BMI and diabetes must be taken into account when interpreting CAP.
Journal ArticleDOI
Chronic Pancreatitis: Challenges and Advances in Pathogenesis, Genetics, Diagnosis, and Therapy
TL;DR: The pancreatic stellate cells are now established as key cells in fibrogenesis, particularly when activated either directly by toxic factors associated with pancreatitis or by cytokines released during pancreatic necroinflammation.
Journal ArticleDOI
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.
Jonas Rosendahl,Heiko Witt,Richárd Szmola,Eesh Bhatia,Béla Ózsvári,Béla Ózsvári,Olfert Landt,Hans Ulrich Schulz,Thomas M. Gress,Roland H. Pfützer,Matthias Löhr,Peter Kovacs,Matthias Blüher,Michael Stumvoll,Gourdas Choudhuri,Péter Hegyi,Rene H. M. te Morsche,Joost P.H. Drenth,Kaspar Truninger,Milan Macek,Gero Puhl,Ulrike Witt,Hartmut Schmidt,Carsten Büning,Johann Ockenga,Andreas Kage,David A. Groneberg,Renate Nickel,Thomas Berg,Bertram Wiedenmann,Hans Bödeker,Volker Keim,Joachim Mössner,Niels Teich,Miklós Sahin-Tóth +34 more
TL;DR: The results indicate that loss-of-function alterations in CTRC predispose to pancreatitis by diminishing its protective trypsin-degrading activity.
Journal ArticleDOI
Variants in CPA1 are strongly associated with early onset chronic pancreatitis
Heiko Witt,Sebastian Beer,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Giriraj R. Chandak,Atsushi Masamune,Melinda Bence,Richárd Szmola,Richárd Szmola,Grzegorz Oracz,Milan Macek,Eesh Bhatia,Sandra Steigenberger,Denise Lasher,Florence Bühler,Catherine Delaporte,Johanna Tebbing,Maren Ludwig,Claudia Pilsak,Karolin Saum,Peter Bugert,Emmanuelle Masson,Emmanuelle Masson,Sumit Paliwal,Seema Bhaskar,Agnieszka Sobczynska-Tomaszewska,Daniel Bak,Ivan Balascak,Gourdas Choudhuri,D. Nageshwar Reddy,G Venkat Rao,Varghese Thomas,Kiyoshi Kume,Eriko Nakano,Yoichi Kakuta,Tooru Shimosegawa,Lukasz Durko,András Szabó,Andrea Schnúr,Andrea Schnúr,Péter Hegyi,Zoltán Rakonczay,Roland H. Pfützer,Alexander Schneider,David A. Groneberg,Markus Braun,Hartmut Schmidt,Ulrike Witt,Helmut Friess,Hana Algül,Olfert Landt,Markus Schuelke,Renate Krüger,Bertram Wiedenmann,Frank Schmidt,Klaus Peter Zimmer,Peter Kovacs,Michael Stumvoll,Matthias Blüher,Thomas Müller,Andreas R. Janecke,Niels Teich,Robert Grützmann,Hans Ulrich Schulz,Joachim Mössner,Volker Keim,Matthias Löhr,Claude Férec,Claude Férec,Miklós Sahin-Tóth +70 more
TL;DR: The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
Journal ArticleDOI
A degradation-sensitive anionic trypsinogen ( PRSS2 ) variant protects against chronic pancreatitis
Heiko Witt,Miklós Sahin-Tóth,Olfert Landt,Jian-Min Chen,Thilo Kähne,Joost P.H. Drenth,Zoltán Kukor,Edit Szepessy,Walter Halangk,Stefan Dahm,Klaus Rohde,Hans Ulrich Schulz,Cédric Le Maréchal,Nejat Akar,Rudolf W. Ammann,Kaspar Truninger,Mario Bargetzi,Eesh Bhatia,Carlo Castellani,Giulia Martina Cavestro,Milos Cerny,Giovanni Destro-Bisol,Gabriella Spedini,Hans Eiberg,Jan B.M.J. Jansen,Monika Koudova,Eva Rausova,Milan Macek,Núria Malats,Francisco X. Real,Hans Jürgen Menzel,Pedro Moral,Roberta Galavotti,Pier Franco Pignatti,Olga Rickards,Julius Spicak,Narcis O. Zarnescu,Wolfgang Böck,Thomas M. Gress,Helmut Friess,Johann Ockenga,Hartmut Schmidt,Roland H. Pfützer,Matthias Löhr,Peter Simon,Frank Ulrich Weiss,Markus M. Lerch,Niels Teich,Volker Keim,Thomas Berg,Bertram Wiedenmann,W Luck,David A. Groneberg,Michael Becker,Thomas Keil,Andreas Kage,Jana Bernardova,Markus Braun,Claudia Güldner,J. Halangk,Jonas Rosendahl,Ulrike Witt,Matthias Treiber,Renate Nickel,Claude Férec +64 more
TL;DR: The G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis.