U
Ulrike Witt
Researcher at Charité
Publications - 3
Citations - 827
Ulrike Witt is an academic researcher from Charité. The author has contributed to research in topics: Pancreatitis & Trypsin. The author has an hindex of 3, co-authored 3 publications receiving 731 citations.
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Journal ArticleDOI
Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis.
Jonas Rosendahl,Heiko Witt,Richárd Szmola,Eesh Bhatia,Béla Ózsvári,Béla Ózsvári,Olfert Landt,Hans Ulrich Schulz,Thomas M. Gress,Roland H. Pfützer,Matthias Löhr,Peter Kovacs,Matthias Blüher,Michael Stumvoll,Gourdas Choudhuri,Péter Hegyi,Rene H. M. te Morsche,Joost P.H. Drenth,Kaspar Truninger,Milan Macek,Gero Puhl,Ulrike Witt,Hartmut Schmidt,Carsten Büning,Johann Ockenga,Andreas Kage,David A. Groneberg,Renate Nickel,Thomas Berg,Bertram Wiedenmann,Hans Bödeker,Volker Keim,Joachim Mössner,Niels Teich,Miklós Sahin-Tóth +34 more
TL;DR: The results indicate that loss-of-function alterations in CTRC predispose to pancreatitis by diminishing its protective trypsin-degrading activity.
Journal ArticleDOI
Variants in CPA1 are strongly associated with early onset chronic pancreatitis
Heiko Witt,Sebastian Beer,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Giriraj R. Chandak,Atsushi Masamune,Melinda Bence,Richárd Szmola,Richárd Szmola,Grzegorz Oracz,Milan Macek,Eesh Bhatia,Sandra Steigenberger,Denise Lasher,Florence Bühler,Catherine Delaporte,Johanna Tebbing,Maren Ludwig,Claudia Pilsak,Karolin Saum,Peter Bugert,Emmanuelle Masson,Emmanuelle Masson,Sumit Paliwal,Seema Bhaskar,Agnieszka Sobczynska-Tomaszewska,Daniel Bak,Ivan Balascak,Gourdas Choudhuri,D. Nageshwar Reddy,G Venkat Rao,Varghese Thomas,Kiyoshi Kume,Eriko Nakano,Yoichi Kakuta,Tooru Shimosegawa,Lukasz Durko,András Szabó,Andrea Schnúr,Andrea Schnúr,Péter Hegyi,Zoltán Rakonczay,Roland H. Pfützer,Alexander Schneider,David A. Groneberg,Markus Braun,Hartmut Schmidt,Ulrike Witt,Helmut Friess,Hana Algül,Olfert Landt,Markus Schuelke,Renate Krüger,Bertram Wiedenmann,Frank Schmidt,Klaus Peter Zimmer,Peter Kovacs,Michael Stumvoll,Matthias Blüher,Thomas Müller,Andreas R. Janecke,Niels Teich,Robert Grützmann,Hans Ulrich Schulz,Joachim Mössner,Volker Keim,Matthias Löhr,Claude Férec,Claude Férec,Miklós Sahin-Tóth +70 more
TL;DR: The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
Journal ArticleDOI
A degradation-sensitive anionic trypsinogen ( PRSS2 ) variant protects against chronic pancreatitis
Heiko Witt,Miklós Sahin-Tóth,Olfert Landt,Jian-Min Chen,Thilo Kähne,Joost P.H. Drenth,Zoltán Kukor,Edit Szepessy,Walter Halangk,Stefan Dahm,Klaus Rohde,Hans Ulrich Schulz,Cédric Le Maréchal,Nejat Akar,Rudolf W. Ammann,Kaspar Truninger,Mario Bargetzi,Eesh Bhatia,Carlo Castellani,Giulia Martina Cavestro,Milos Cerny,Giovanni Destro-Bisol,Gabriella Spedini,Hans Eiberg,Jan B.M.J. Jansen,Monika Koudova,Eva Rausova,Milan Macek,Núria Malats,Francisco X. Real,Hans Jürgen Menzel,Pedro Moral,Roberta Galavotti,Pier Franco Pignatti,Olga Rickards,Julius Spicak,Narcis O. Zarnescu,Wolfgang Böck,Thomas M. Gress,Helmut Friess,Johann Ockenga,Hartmut Schmidt,Roland H. Pfützer,Matthias Löhr,Peter Simon,Frank Ulrich Weiss,Markus M. Lerch,Niels Teich,Volker Keim,Thomas Berg,Bertram Wiedenmann,W Luck,David A. Groneberg,Michael Becker,Thomas Keil,Andreas Kage,Jana Bernardova,Markus Braun,Claudia Güldner,J. Halangk,Jonas Rosendahl,Ulrike Witt,Matthias Treiber,Renate Nickel,Claude Férec +64 more
TL;DR: The G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis.