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Yoichi Kakuta
Researcher at Tohoku University
Publications - 117
Citations - 1770
Yoichi Kakuta is an academic researcher from Tohoku University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 84 publications receiving 1305 citations.
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Journal ArticleDOI
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.
Kouichi Asano,Tomonaga Matsushita,Junji Umeno,Naoya Hosono,Atsushi Takahashi,Takahisa Kawaguchi,Takayuki Matsumoto,Toshiyuki Matsui,Yoichi Kakuta,Yoshitaka Kinouchi,Tooru Shimosegawa,Masayo Hosokawa,Yoshiaki Arimura,Yasuhisa Shinomura,Yutaka Kiyohara,Tatsuhiko Tsunoda,Naoyuki Kamatani,Mitsuo Iida,Yusuke Nakamura,Michiaki Kubo +19 more
TL;DR: A two-stage genome-wide association study and subsequent replication study using 1,384 Japanese individuals with ulcerative colitis and 3,057 control subjects provides insight into the molecular pathogenesis of ulceratives colitis.
Journal ArticleDOI
Variants in CPA1 are strongly associated with early onset chronic pancreatitis
Heiko Witt,Sebastian Beer,Jonas Rosendahl,Jian-Min Chen,Jian-Min Chen,Giriraj R. Chandak,Atsushi Masamune,Melinda Bence,Richárd Szmola,Richárd Szmola,Grzegorz Oracz,Milan Macek,Eesh Bhatia,Sandra Steigenberger,Denise Lasher,Florence Bühler,Catherine Delaporte,Johanna Tebbing,Maren Ludwig,Claudia Pilsak,Karolin Saum,Peter Bugert,Emmanuelle Masson,Emmanuelle Masson,Sumit Paliwal,Seema Bhaskar,Agnieszka Sobczynska-Tomaszewska,Daniel Bak,Ivan Balascak,Gourdas Choudhuri,D. Nageshwar Reddy,G Venkat Rao,Varghese Thomas,Kiyoshi Kume,Eriko Nakano,Yoichi Kakuta,Tooru Shimosegawa,Lukasz Durko,András Szabó,Andrea Schnúr,Andrea Schnúr,Péter Hegyi,Zoltán Rakonczay,Roland H. Pfützer,Alexander Schneider,David A. Groneberg,Markus Braun,Hartmut Schmidt,Ulrike Witt,Helmut Friess,Hana Algül,Olfert Landt,Markus Schuelke,Renate Krüger,Bertram Wiedenmann,Frank Schmidt,Klaus Peter Zimmer,Peter Kovacs,Michael Stumvoll,Matthias Blüher,Thomas Müller,Andreas R. Janecke,Niels Teich,Robert Grützmann,Hans Ulrich Schulz,Joachim Mössner,Volker Keim,Matthias Löhr,Claude Férec,Claude Férec,Miklós Sahin-Tóth +70 more
TL;DR: The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
Journal ArticleDOI
NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD
Yoichi Kakuta,Takeo Naito,Motoyuki Onodera,Masatake Kuroha,Tomoya Kimura,Hisashi Shiga,Katsuya Endo,Kenichi Negoro,Yoshitaka Kinouchi,Toru Shimosegawa +9 more
TL;DR: NUDT R139C was significantly associated with early severe hair loss in Japanese patients with IBD and it is recommended that treatment with thiopurines should be avoided for patients with the T/T genotype.
Journal ArticleDOI
NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study
Yoichi Kakuta,Yosuke Kawai,Daisuke Okamoto,Tetsuya Takagawa,Kentaro Ikeya,Hirotake Sakuraba,Atsushi Nishida,Shoko Nakagawa,Miki Miura,Takahiko Toyonaga,Kei Onodera,Masaru Shinozaki,Yoh Ishiguro,Shinta Mizuno,Masahiro Takahara,Shunichi Yanai,Ryota Hokari,T. Nakagawa,Hiroshi Araki,Satoshi Motoya,Takeo Naito,Rintaro Moroi,Hisashi Shiga,Katsuya Endo,Taku Kobayashi,Makoto Naganuma,Sakiko Hiraoka,Takayuki Matsumoto,Shiro Nakamura,Hiroshi Nakase,Tadakazu Hisamatsu,Makoto Sasaki,Hiroyuki Hanai,Akira Andoh,Masao Nagasaki,Yoshitaka Kinouchi,Tooru Shimosegawa,Atsushi Masamune,Yasuo Suzuki +38 more
TL;DR: Genotyping of NUDT15 codon 139 was sufficient to predict acute severe leukopenia and alopecia in Japanese patients with IBD and no additional variants were found to be associated with thiopurine-induced AEs.
Journal ArticleDOI
Association study of TNFSF15 polymorphisms in Japanese patients with inflammatory bowel disease
TL;DR: To investigate this possible association between TNFSF15 and Japanese UC, and to replicate this association with CD in Japanese, a case control association study in Japanese patients was performed.