G
Gabriel G. Haddad
Researcher at University of California, San Diego
Publications - 353
Citations - 17821
Gabriel G. Haddad is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Hypoxia (medical) & Gene. The author has an hindex of 65, co-authored 337 publications receiving 16316 citations. Previous affiliations of Gabriel G. Haddad include University of Iowa & University of California, Los Angeles.
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Journal ArticleDOI
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Jordi Rius,Monica Guma,Christian Schachtrup,Katerina Akassoglou,Annelies S. Zinkernagel,Victor Nizet,Randall S. Johnson,Gabriel G. Haddad,Michael Karin +8 more
TL;DR: It is shown, with the use of mice lacking IKK-β in different cell types, that NF-κB is a critical transcriptional activator of HIF-1α and that basal NF-σB activity is required for Hif-1 α protein accumulation under hypoxia in cultured cells and in the liver and brain of hypoxic animals.
Journal ArticleDOI
Standards and indications for cardiopulmonary sleep studies in children
Gerald M. Loughlin,Robert T. Brouillette,L. J. Brooke,John L. Carroll,B. E. Chipps,S. J. England,P. Ferber,N. F. Ferraro,Claude Gaultier,D. C. Givan,Gabriel G. Haddad,B. R. Maddern,George B. Mallory,I. T. Nathanson,Carol L. Rosen,B. T. Thach,S. L. Davidson Ward,Debra E. Weese-Mayer,M. E. Wohl +18 more
Journal ArticleDOI
A critical role of neural-specific JNK3 for ischemic apoptosis.
Chia-Yi Kuan,Alan J. Whitmarsh,Alan J. Whitmarsh,Derek D. Yang,Derek D. Yang,Guanghong Liao,Aryn Schloemer,Chen Dong,Jue Bao,Kenneth J. Banasiak,Kenneth J. Banasiak,Gabriel G. Haddad,Gabriel G. Haddad,Richard A. Flavell,Roger J. Davis,Pasko Rakic +15 more
TL;DR: It is shown that JNK1 is the major isoform responsible for the high level of basal JNK activity in the brain, and targeted deletion of Jnk3 not only reduces the stress-induced J NK activity, but also protects mice from brain injury after cerebral ischemia–hypoxia.
Journal ArticleDOI
Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.
Cleber A. Trujillo,Richard Gao,Priscilla D. Negraes,Jing Gu,Justin Buchanan,Sebastian Preissl,Allen Wang,Wei Wu,Gabriel G. Haddad,Isaac A. Chaim,Alain Domissy,Matthieu Vandenberghe,Anna Devor,Gene W. Yeo,Bradley Voytek,Alysson R. Muotri +15 more
TL;DR: Human cortical organoids that dynamically change cellular populations during maturation and exhibited consistent increases in electrical activity over the span of several months show that the development of structured network activity in a human neocortex model may follow stable genetic programming.