Matthieu Vandenberghe

TL;DR: Human cortical organoids that dynamically change cellular populations during maturation and exhibited consistent increases in electrical activity over the span of several months show that the development of structured network activity in a human neocortex model may follow stable genetic programming.

TL;DR: It is demonstrated that selective activation of cortical excitation and inhibition elicits distinct vascular responses and the vasoconstrictive mechanism is identified as Neuropeptide Y (NPY) acting on Y1 receptors, implying that task-related negative Blood Oxygenation Level Dependent fMRI signals in the cerebral cortex under normal physiological conditions may be mainly driven by the NPY-positive inhibitory neurons.

TL;DR: Optical imaging and manipulation technologies cannot be easily integrated with electrical recordings due to generation of light-induced artifacts, so transparent graphene microelectrode fabrication is reported to achieve artifact-free electrical recordings along with deep 2-photon imaging in vivo.

TL;DR: A detailed ‘bottom-up’ forward model bridging neuronal activity at the level of cell-type-specific populations to non-invasive imaging signals would provide the ‘ground truth’ for the development of new tools for tackling the inverse problem—estimation of neuronal activity from multimodal non- invasive imaging data.

TL;DR: Salinas et al. as discussed by the authors proposed a new class of fluorescent, voltage-sensitive dyes, sulfonated rhodamine voltage reporters (sRhoVR), with high voltage sensitivity, excellent two-photon performance, and compatibility in intact mouse brains.