G
Gail Barker
Researcher at Newcastle University
Publications - 8
Citations - 1300
Gail Barker is an academic researcher from Newcastle University. The author has contributed to research in topics: Lynch syndrome & Cancer. The author has an hindex of 6, co-authored 8 publications receiving 1207 citations.
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Journal ArticleDOI
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
John Burn,Anne-Marie Gerdes,Finlay A. Macrae,Jukka-Pekka Mecklin,Gabriela Moeslein,Sylviane Olschwang,D. Eccles,D. Gareth Evans,Eamonn R. Maher,Lucio Bertario,Marie Luise Bisgaard,Malcolm G. Dunlop,Judy W. C. Ho,Shirley V. Hodgson,Annika Lindblom,Jan Lubinski,Patrick J. Morrison,Victoria Murday,Raj Ramesar,Lucy Side,Rodney J. Scott,Huw Thomas,Hans F. A. Vasen,Gail Barker,Gillian Crawford,Faye Elliott,Mohammad Movahedi,Kirsi Pylvänäinen,Juul T. Wijnen,Riccardo Fodde,Henry T. Lynch,John C. Mathers,D. Timothy Bishop +32 more
TL;DR: The CAPP2 trial aimed to investigate the antineoplastic effects of aspirin and a resistant starch in carriers of Lynch syndrome, the major form of hereditary colorectal cancer, and long-term follow-up of participants randomly assigned to aspirin or placebo is reported.
Journal ArticleDOI
Effect of Aspirin or Resistant Starch on Colorectal Neoplasia in the Lynch Syndrome
John Burn,D. Timothy Bishop,Jukka-Pekka Mecklin,Finlay A. Macrae,Gabriela Möslein,Sylviane Olschwang,Marie Luise Bisgaard,Raj Ramesar,Diana Eccles,Eamonn R. Maher,Lucio Bertario,Heikki Järvinen,Annika Lindblom,D. Gareth Evans,Jan Lubinski,Patrick J. Morrison,Judy W. C. Ho,Hans F. A. Vasen,Lucy Side,Huw Thomas,Rodney J. Scott,Malcolm G. Dunlop,Gail Barker,Faye Elliott,Jeremy R. Jass,Ricardo Fodde,Henry T. Lynch,John C. Mathers +27 more
TL;DR: The use of aspirin, resistant starch, or both for up to 4 years has no effect on the incidence of colorectal adenoma or carcinoma among carriers of the Lynch syndrome.
Journal ArticleDOI
Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
John C. Mathers,Mohammad Movahedi,Mohammad Movahedi,Finlay A. Macrae,Jukka-Pekka Mecklin,Gabriela Moeslein,Sylviane Olschwang,Diana Eccles,Gareth Evans,Eamonn R. Maher,Lucio Bertario,Marie Luise Bisgaard,Malcolm G. Dunlop,Judy W. C. Ho,Shirley V. Hodgson,Annika Lindblom,Jan Lubinski,Patrick J. Morrison,Victoria Murday,Raj Ramesar,Lucy Side,Rodney J. Scott,Huw Thomas,Hans F. A. Vasen,Anne-Marie Gerdes,Gail Barker,Gillian Crawford,Faye Elliott,Kirsi Pylvänäinen,Juul T. Wijnen,Riccardo Fodde,Henry T. Lynch,D. Timothy Bishop,John Burn +33 more
TL;DR: Dietary supplementation with resistant starch does not emulate the apparently protective effect of diets rich in dietary fibre against colorectal cancer and has no detectable effect on cancer development in carriers of hereditary coloreCTal cancer.
Journal ArticleDOI
Prevalence of Adenomas and Hyperplastic Polyps in Mismatch Repair Mutation Carriers Among CAPP2 Participants: Report by the Colorectal Adenoma/Carcinoma Prevention Programme 2
Annelie Liljegren,Gail Barker,Faye Elliott,Lucio Bertario,Marie Luise Bisgaard,Diana Eccles,Gareth J.O. Evans,Finlay A. Macrae,Eamonn R. Maher,Annika Lindblom,Samuel Rotstein,Bo Nilsson,Jukka-Pekka Mecklin,Gabriela Möslein,Jeremy R. Jass,Riccardo Fodde,John C. Mathers,John Burn,D. Timothy Bishop +18 more
TL;DR: Adenoma prevalence increases with age among MMR mutation carriers, whereas hyperplastic polyp prevalence is consistent, and a marginal association was found between the co-occurrence of adenomas and hyperplastics polyps.
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer
John Burn,Anne-Marie Gerdes,Finlay A. Macrae,Jukka-Pekka Mecklin,Gabriela Moeslein,Sylviane Olschwang,D. Eccles,D. Gareth Evans,Eamonn R. Maher,Lucio Bertario,Marie Luise Bisgaard,Malcolm G. Dunlop,Judy W. C. Ho,Shirley V. Hodgson,Annika Lindblom,Jan Lubinski,Patrick J. Morrison,Victoria Murday,Raj Ramesar,Lucy Side,Rodney J. Scott,Huw Thomas,Hans F. A. Vasen,Gail Barker,Gillian Crawford,Faye Elliott,Mohammad Movahedi,Kirsi Pylvänäinen,Juul T. Wijnen,Riccardo Fodde +29 more
TL;DR: The long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial is described.