D
D. Eccles
Researcher at University of Edinburgh
Publications - 23
Citations - 1673
D. Eccles is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Cancer & Breast cancer. The author has an hindex of 13, co-authored 22 publications receiving 1578 citations. Previous affiliations of D. Eccles include Princess Anne Hospital.
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Journal ArticleDOI
Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial
John Burn,Anne-Marie Gerdes,Finlay A. Macrae,Jukka-Pekka Mecklin,Gabriela Moeslein,Sylviane Olschwang,D. Eccles,D. Gareth Evans,Eamonn R. Maher,Lucio Bertario,Marie Luise Bisgaard,Malcolm G. Dunlop,Judy W. C. Ho,Shirley V. Hodgson,Annika Lindblom,Jan Lubinski,Patrick J. Morrison,Victoria Murday,Raj Ramesar,Lucy Side,Rodney J. Scott,Huw Thomas,Hans F. A. Vasen,Gail Barker,Gillian Crawford,Faye Elliott,Mohammad Movahedi,Kirsi Pylvänäinen,Juul T. Wijnen,Riccardo Fodde,Henry T. Lynch,John C. Mathers,D. Timothy Bishop +32 more
TL;DR: The CAPP2 trial aimed to investigate the antineoplastic effects of aspirin and a resistant starch in carriers of Lynch syndrome, the major form of hereditary colorectal cancer, and long-term follow-up of participants randomly assigned to aspirin or placebo is reported.
Journal ArticleDOI
Psychosocial impact of breast/ovarian (BRCA1/2) cancer-predictive genetic testing in a UK multi-centre clinical cohort
Maggie Watson,Claire Foster,Rosalind A. Eeles,D. Eccles,Stanley W. Ashley,Rosemarie Davidson,James W. MacKay,Patrick J. Morrison,Penelope Hopwood,D. G. R. Evans +9 more
TL;DR: The data show persistent worry in younger female gene carriers and confirm changes in risk management consistent with carrier status, and men were not adversely affected by genetic testing in terms of their general mental health.
Journal ArticleDOI
Analysis of genetic and phenotypic heterogeneity in juvenile polyposis.
Kelly Woodford-Richens,Steve Bevan,Michael Churchman,B Dowling,Daniel Jones,C. G. Norbury,Shirley Hodgson,Devendra Desai,K Neale,R. K. S. Phillips,Joanne P. Young,Barbara A. Leggett,Malcolm G. Dunlop,Paul Rozen,Charis Eng,David Markie,Miguel A. Rodriguez-Bigas,Eamonn Sheridan,Takeo Iwama,D. Eccles,G T Smith,Jin Cheon Kim,Kang Mo Kim,Julian R. Sampson,G Evans,Sabine Tejpar,Walter F. Bodmer,I P M Tomlinson,Richard S. Houlston +28 more
TL;DR: Mutations in PTEN and PTCH are unlikely to cause juvenile polyposis in the absence of clinical features indicative of CS, BRRS, or GS, and a proportion of JPS patients harbour DPC4 mutations but there remains uncharacterised genetic heterogeneity in JPS.
Journal ArticleDOI
Current policies for surveillance and management in women at risk of breast and ovarian cancer: a survey among 16 European family cancer clinics. European Familial Breast Cancer Collaborative Group.
Hans F. A. Vasen,Neva E. Haites,D. G. R. Evans,C. M. Steel,Pål Møller,Shirley Hodgson,D. Eccles,Patrick J. Morrison,D Stoppa Lyonet,Jenny Chang-Claude,Ma Caligo +10 more
TL;DR: Insight is provided into the guidelines for surveillance and management of familial breast cancer used at various family cancer clinics in Europe; this insight may contribute to the appropriate management of these high risk women.
Journal ArticleDOI
Predictive testing for BRCA1/2: attributes, risk perception and management in a multi-centre clinical cohort
Claire Foster,D. G. R. Evans,Rosalind A. Eeles,D. Eccles,Stanley W. Ashley,L. Brooks,Rosemarie Davidson,James W. MacKay,Patrick J. Morrison,Maggie Watson +9 more
TL;DR: In this paper, the authors examined the attributes of a cohort offered predictive genetic testing for breast/ovarian cancer predisposition, and found that younger women are more worried about developing cancer than older women.