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Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial

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TLDR
The CAPP2 trial aimed to investigate the antineoplastic effects of aspirin and a resistant starch in carriers of Lynch syndrome, the major form of hereditary colorectal cancer, and long-term follow-up of participants randomly assigned to aspirin or placebo is reported.
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This article is published in The Lancet.The article was published on 2011-12-17 and is currently open access. It has received 828 citations till now. The article focuses on the topics: Aspirin & European union.

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Citations
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The gut microbiota, bacterial metabolites and colorectal cancer

TL;DR: The relationship between diet, microbial metabolism and CRC is discussed and it is argued that the cumulative effects of microbial metabolites should be considered in order to better predict and prevent cancer progression.
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ESMO Consensus Guidelines for management of patients with colon and rectal cancer. A personalized approach to clinical decision making

TL;DR: This ESMO guideline is recommended to be used as the basis for treatment and management decisions, delivering a clear proposal for diagnostic and treatment measures in each stage of rectal and colon cancer and the individual clinical situations.
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ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.

TL;DR: Patients who meet clinical criteria for a syndrome as well as those with identified pathogenic germline mutations should receive appropriate surveillance measures in order to minimize their overall risk of developing syndrome-specific cancers.
References
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Journal ArticleDOI

New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

TL;DR: The establishment of a set of selection criteria for families with hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) to provide a basis for uniformity in collaborative studies and a definition of HNPCC was proposed that was aimed at helping clinicians to identify families.
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Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials.

TL;DR: Benefit increased with duration of treatment and was consistent across the different study populations, having implications for guidelines on use of aspirin and for understanding of carcinogenesis and its susceptibility to drug intervention.
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Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials.

TL;DR: Benefit was greatest for cancers of the proximal colon, which are not otherwise prevented effectively by screening with sigmoidoscopy or colonoscopy, and benefit increased with scheduled duration of treatment.
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Aspirin and the risk of colorectal cancer in women.

TL;DR: Regular aspirin use, at doses similar to those recommended for the prevention of cardiovascular disease, substantially reduces the risk of colorectal cancer, however, this benefit may not be evident until after at least a decade of regular aspirin consumption.
Journal ArticleDOI

Effect of aspirin on long-term risk of colorectal cancer: consistent evidence from randomised and observational studies

E Flossmann, +1 more
- 12 May 2007 - 
TL;DR: Regular use of aspirin or NSAID was consistently associated with a reduced risk of colorectal cancer, especially after use for 10 years or more, with no difference between aspirin and other NSAIDs, or in relation to age, sex, race, or family history, site or aggressiveness of cancer.
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Q1. What have the authors contributed in "Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the capp2 randomised controlled trial" ?

The long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial was presented in this paper.