G
Geoffrey M. Silver
Researcher at Loyola University Chicago
Publications - 27
Citations - 1350
Geoffrey M. Silver is an academic researcher from Loyola University Chicago. The author has contributed to research in topics: Burn injury & Proteome. The author has an hindex of 21, co-authored 27 publications receiving 1308 citations. Previous affiliations of Geoffrey M. Silver include University of Vermont.
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Journal ArticleDOI
Quantitative Proteome Analysis of Human Plasma following in Vivo Lipopolysaccharide Administration Using 16O/18O Labeling and the Accurate Mass and Time Tag Approach
Wei-Jun Qian,Matthew E. Monroe,Tao Liu,Jon M. Jacobs,Gordon A. Anderson,Yufeng Shen,Ronald J. Moore,David J. Anderson,Rui Zhang,Steve E. Calvano,Stephen F. Lowry,Wenzhong Xiao,Lyle L. Moldawer,Ronald W. Davis,Ronald G. Tompkins,David G. Camp,Richard D. Smith,Henry V. Baker,Paul E. Bankey,Timothy R. Billiar,Bernard H. Brownstein,Irshad H. Chaudry,J. Perren Cobb,Adrian Fay,Robert J. Feezor,Brad Freeman,Richard L. Gamelli,Nicole S. Gibran,Brian G. Harbrecht,Doug Hayden,David N. Herndon,Jureta W. Horton,John L. Hunt,Jeffrey L. Johnson,Krzystof Laudanski,James A. Lederer,Tanya Logvinenko,Ronald V. Maier,John A. Mannick,Bruce A. McKinley,Carol L. Miller-Graziano,Joseph P. Minei,Michael N. Mindrinos,Ernest E. Moore,F. A. Moore,Avery B. Nathens,Grant E. O'Keefe,Laurence G. Rahme,Daniel G. Remick,David A. Schoenfeld,Michael B. Shapiro,Robert L. Sheridan,Geoffrey M. Silver,Scott Somers,Mehmet Toner,H. Shaw Warren,Michael West,Steven E. Wolf,Martin L. Yarmush,Vernon R. Young +59 more
TL;DR: An initial demonstration of proteome-wide quantitative analysis of human plasma using postdigestion trypsin-catalyzed 16O/18O peptide labeling, two-dimensional LC-FTICR mass spectrometry, and the accurate mass and time (AMT) tag strategy to identify and quantify peptides/proteins from complex samples is described.
Journal ArticleDOI
Toxic epidermal necrolysis: does immunoglobulin make a difference?
Kimberly M. Brown,Geoffrey M. Silver,Marcia Halerz,P. S. Walaszek,Alvaro Sandroni,Richard L. Gamelli +5 more
TL;DR: A multicenter, prospective, double-blinded randomized trial is necessary and urgently indicated to determine whether Ig therapy is beneficial or harmful in the care of TEN patients.
Journal ArticleDOI
High Dynamic Range Characterization of the Trauma Patient Plasma Proteome
Tao Liu,Wei Jun Qiant,Marina A. Gritsenko,Wenzhong Xiao,Lyle L. Moldawer,Amit Kaushal,Matthew E. Monroe,Susan M. Varnum,Ronald J. Moore,Samuel O. Purvine,Ronald V. Maier,Ronald W. Davis,Ronald G. Tompkins,David G. Camp,Richard D. Smith,Henry V. Baker,Paul E. Bankey,Timothy R. Billiar,Bernard H. Brownstein,Steve E. Calvano,Celeste Campbell-Finnerty,George Casella,Irshad H. Chaudry,Mashkoor A. Choudhry,J. Perren Cobb,Asit De,Constance Elson,Bradley D. Freeman,Richard L. Gamelli,Nicole S. Gibran,Brian G. Harbrecht,Douglas Hayden,David N. Herndon,Jureta W. Horton,William J. Hubbard,John L. Hunt,Jeffrey L. Johnson,Matthew B. Klein,James A. Lederer,Tanya Logvinenko,Stephen F. Lowry,John A. Mannick,Philip H. Mason,Grace P. McDonald-Smith,Bruce A. McKinley,Carol L. Miller-Graziano,Michael N. Mindrinos,Joseph P. Minei,Ernest E. Moore,F. A. Moore,Avery B. Nathens,Grant E. O'Keefe,Laurence G. Rahme,Daniel G. Remick,David A. Schoenfeld,Michael B. Shapiro,Martin G. Schwacha,Geoffrey M. Silver,John D. Storey,Mehmet Toner,H. Shaw Warren,Michael West +61 more
TL;DR: This study established an extensive reference protein database for trauma patients that provides a foundation for future high throughput quantitative plasma proteomic studies designed to elucidate the mechanisms that underlie systemic inflammatory responses.
Journal ArticleDOI
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways
Krzysztof Laudanski,Carol L. Miller-Graziano,Wenzhong Xiao,Michael N. Mindrinos,Daniel R. Richards,Asit De,Lyle L. Moldawer,Ronald V. Maier,Paul E. Bankey,Henry V. Baker,Henry V. Baker,Bernard H. Brownstein,J. Perren Cobb,Steve E. Galvano,Ronald W. Davis,Ronald G. Tompkins,Timothy R. Billiar,David G. Camp,Celeste Campbell-Finnerty,George Casella,Irshad H. Chaudry,Mashkoor A. Choudhry,Constance Elson,Bradley D. Freeman,Richard L. Gamelli,Nicole S. Gibran,Brian G. Harbrecht,Douglas Hayden,David N. Herndon,Jureta W. Horton,William J. Hubbard,John L. Hunt,Jeffrey L. Johnson,Matthew B. Klein,James A. Lederer,Tanya Logvinenko,Stephen F. Lowry,John A. Mannick,Philip H. Mason,Grace P. McDonald-Smith,Bruce A. McKinley,Joseph P. Minei,Ernest E. Moore,Frederick A. Moore,Avery B. Nathens,Grant E. O'Keefe,Laurence G. Rahme,Daniel G. Remick,David A. Schoenfeld,Michael B. Shapiro,Martin G. Schwacha,Geoffrey M. Silver,Richard D. Smith,John D. Storey,Mehmet Toner,H. Shaw Warren,Michael West +56 more
TL;DR: Genome-wide expression analysis of highly enriched circulating leukocyte subpopulations, combined with cell-specific pathway analyses, offers an opportunity to discover leukocytes regulatory networks in critically injured patients.
Journal ArticleDOI
Treatment of intra-abdominal infection with granulocyte colony-stimulating factor.
Michael O'Reilly,Geoffrey M. Silver,David G. Greenhalgh,Richard L. Gamelli,John E. Davis,James C. Hebert +5 more
TL;DR: The use of a neutrophil growth factor, recombinant human granulocyte colony-stimulating factor (G-CSF), to improve survival in a well-established sepsis model, cecal ligation and puncture (CLP), resulted in a dose-dependent improvement in survival.