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Kevin Rue-Albrecht
Researcher at University of Oxford
Publications - 31
Citations - 1707
Kevin Rue-Albrecht is an academic researcher from University of Oxford. The author has contributed to research in topics: Mycobacterium bovis & Transcriptome. The author has an hindex of 13, co-authored 28 publications receiving 1035 citations. Previous affiliations of Kevin Rue-Albrecht include Newcastle upon Tyne Hospitals NHS Foundation Trust & University College Dublin.
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Journal ArticleDOI
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.
Julie Schulthess,Julie Schulthess,Sumeet Pandey,Melania Capitani,Kevin Rue-Albrecht,Isabelle C. Arnold,Fanny Franchini,Agnieszka Chomka,Nicholas E. Ilott,Daniel G.W. Johnston,Elisabete Pires,James S. O. McCullagh,Stephen N. Sansom,Carolina V. Arancibia-Cárcamo,Holm H. Uhlig,Fiona Powrie,Fiona Powrie +16 more
TL;DR: The data suggest that increased intestinal butyrate might represent a strategy to bolster host defense without tissue damaging inflammation and that pharmacological HDAC3 inhibition might drive selective macrophage functions toward antimicrobial host defense.
Journal ArticleDOI
Orchestrating Single-Cell Analysis with Bioconductor
Robert A. Amezquita,Aaron T. L. Lun,Aaron T. L. Lun,Etienne Becht,Vincent J. Carey,Lindsay N. Carpp,Ludwig Geistlinger,Federico Marini,Kevin Rue-Albrecht,Davide Risso,Davide Risso,Charlotte Soneson,Charlotte Soneson,Levi Waldron,Hervé Pagès,Mike L. Smith,Wolfgang Huber,Martin Morgan,Raphael Gottardo,Stephanie C. Hicks +19 more
TL;DR: This Perspective highlights open-source software for single-cell analysis released as part of the Bioconductor project, providing an overview for users and developers.
Journal ArticleDOI
Genome sequencing of the extinct Eurasian wild aurochs, Bos primigenius, illuminates the phylogeography and evolution of cattle.
Stephen D. E. Park,David A. Magee,David A. Magee,Paul A. McGettigan,Matthew D. Teasdale,Ceiridwen J. Edwards,Amanda J. Lohan,Alison Murphy,Martin Braud,Mark T.A. Donoghue,Yuan Liu,Andrew T. Chamberlain,Kevin Rue-Albrecht,Steven G. Schroeder,Charles Spillane,Shuaishuai Tai,Daniel G. Bradley,Tad S. Sonstegard,Brendan J. Loftus,David E. MacHugh +19 more
TL;DR: Phylogenomic analyses place the aurochs as a distinct outgroup to the domestic B. taurus lineage, supporting the predominant Near Eastern origin of European cattle, and reveals that the interface between early European domestic populations and wild auroChs was significantly more complex than previously thought.
Journal ArticleDOI
Plasma Metabolomics Implicates Modified Transfer RNAs and Altered Bioenergetics in the Outcomes of Pulmonary Arterial Hypertension.
Christopher J. Rhodes,Pavandeep Ghataorhe,John Wharton,Kevin Rue-Albrecht,Charaka Hadinnapola,Geoffrey Watson,Marta Bleda,Matthias Haimel,Gerry Coghlan,Paul A. Corris,Luke Howard,David G. Kiely,Andrew J. Peacock,Joanna Pepke-Zaba,Mark Toshner,S. John Wort,J. Simon R. Gibbs,Allan Lawrie,Stefan Gräf,Nicholas W. Morrell,Martin R. Wilkins +20 more
TL;DR: Metabolic profiles in PAH are strongly related to survival and should be considered part of the deep phenotypic characterization of this disease.
Journal ArticleDOI
iSEE: Interactive SummarizedExperiment Explorer
TL;DR: The iSEE (Interactive SummarizedExperiment Explorer) software package is presented, which provides a general visual interface for exploring data in a SummarizationExperiment object, and provides useful features such as simultaneous examination of (meta)data and analysis results, dynamic linking between plots and code tracking for reproducibility.