Stephan Schlickeiser

TL;DR: This study provides detailed insights into the systemic immune response to SARS-CoV-2 infection and it reveals profound alterations in the myeloid cell compartment associated with severe COVID-19.

TL;DR: The phenotypic signature of hu MG was identified, which was distinct from peripheral myeloid cells but was comparable to fresh huMG, and microglia regional heterogeneity was identified.

TL;DR: In this paper, the authors evaluated the safety of regulatory CBMPs when combined with reduced immunosuppressive treatment in kidney transplant patients and found that CBMP is achievable and safe in living-donor kidney transplant recipients, and is associated with fewer infectious complications, but similar rejection rates in the first year.

TL;DR: The ONE Study panel may be adopted as a standardized method for monitoring patients in clinical trials enrolling transplant patients, particularly trials of novel tolerance promoting therapies, to facilitate fair and meaningful comparisons between trials.

TL;DR: Deep epigenomes comprising genome-wide profiles of DNA methylation, histone modifications, DNA accessibility, and coding and non-coding RNA expression in naive, central-, effector-, and terminally differentiated Tmem cells from blood and bone marrow were generated and candidate master regulators of Tmem cell differentiation were identified.