G
George D. Kalliolias
Researcher at Hospital for Special Surgery
Publications - 40
Citations - 2896
George D. Kalliolias is an academic researcher from Hospital for Special Surgery. The author has contributed to research in topics: Tumor necrosis factor alpha & Arthritis. The author has an hindex of 21, co-authored 38 publications receiving 2290 citations. Previous affiliations of George D. Kalliolias include University of Patras & Cornell University.
Papers
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Journal ArticleDOI
TNF biology, pathogenic mechanisms and emerging therapeutic strategies
TL;DR: Molecular mechanisms underlying the roles of T NF in homeostasis and inflammatory disease pathogenesis are presented, and novel strategies to advance therapeutic paradigms for the treatment of TNF-mediated diseases are discussed.
Journal ArticleDOI
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis
Fumitaka Mizoguchi,Kamil Slowikowski,Kevin Wei,Jennifer L. Marshall,Deepak A. Rao,Sook Kyung Chang,Hung N. Nguyen,Erika H. Noss,Erika H. Noss,Jason D. Turner,Brandon E. Earp,Philip E. Blazar,John Wright,Barry P. Simmons,Laura T. Donlin,George D. Kalliolias,Susan M. Goodman,Susan M. Goodman,Vivian P. Bykerk,Vivian P. Bykerk,Lionel B. Ivashkiv,Lionel B. Ivashkiv,James A. Lederer,Nir Hacohen,Peter A. Nigrovic,Peter A. Nigrovic,Andrew Filer,Christopher D. Buckley,Soumya Raychaudhuri,Michael B. Brenner +29 more
TL;DR: Functional and transcriptional differences between fibroblast subsets from human synovial tissues are shown using bulk transcriptomics of targeted subpopulations and single-cell transcriptomics for rheumatoid arthritis.
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iRHOM2 is a critical pathogenic mediator of inflammatory arthritis
Priya D. Issuree,Thorsten Maretzky,David R. McIlwain,David R. McIlwain,David R. McIlwain,Sebastien Monette,Xiaoping Qing,Philipp A. Lang,Steven L. Swendeman,Kyung-Hyun Park-Min,Nikolaus B. Binder,George D. Kalliolias,Anna Yarilina,Keisuke Horiuchi,Lionel B. Ivashkiv,Lionel B. Ivashkiv,Tak W. Mak,Tak W. Mak,Jane E. Salmon,Jane E. Salmon,Carl P. Blobel,Carl P. Blobel +21 more
TL;DR: It is reported that inactivation of Rhbdf2 allows tissue-specific regulation of TACE by selectively preventing its maturation in immune cells, without affecting its homeostatic functions in other tissues.
Journal ArticleDOI
Indirect Inhibition of Toll-like Receptor and Type I Interferon Responses by ITAM-Coupled Receptors and Integrins
Lu Wang,Rachael A. Gordon,Linda Huynh,Linda Huynh,Xiaodi Su,Xiaodi Su,Kyung-Hyun Park Min,Jiahuai Han,J. Simon C. Arthur,George D. Kalliolias,Lionel B. Ivashkiv,Lionel B. Ivashkiv +11 more
TL;DR: This work shows that high-avidity ligation of ITAM-coupled beta2 integrins and FcgammaRs in macrophages inhibited type I interferon receptor and Toll-like receptor (TLR) signaling and induced expression of interleukin-10 (IL-10) and delineate a signaling pathway important for deactivation of macrophage.
Journal ArticleDOI
Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages
Antigoni Triantafyllopoulou,Claus-Werner Franzke,Surya V. Seshan,Giorgio Perino,George D. Kalliolias,Meera Ramanujam,Nico van Rooijen,Anne Davidson,Lionel B. Ivashkiv +8 more
TL;DR: A model of polyinosinic: polycytidylic acid-accelerated lupus nephritis in NZB/W mice is described that is characterized by severe glomerular proliferative lesions with de novo crescent formation, findings that are linked with decreased survival and adverse outcomes in l upus.