G
Gert Storm
Researcher at Utrecht University
Publications - 546
Citations - 36914
Gert Storm is an academic researcher from Utrecht University. The author has contributed to research in topics: Liposome & Drug delivery. The author has an hindex of 96, co-authored 530 publications receiving 32703 citations. Previous affiliations of Gert Storm include National University of Singapore & University of Groningen.
Papers
More filters
Journal ArticleDOI
Endosomal escape pathways for delivery of biologicals
TL;DR: In this article, the authors introduced several mechanisms and agents which are involved in endosomal escape, including pore formation, pH buffering effect of protonable groups and fusion into the lipid bilayer of endosomes.
Journal ArticleDOI
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
Raymond M. Schiffelers,Aslam M. Ansari,Jun Xu,Qin Zhou,Qingquan Tang,Gert Storm,Grietje Molema,Patrick Y. Lu,Puthupparampil V. Scaria,Martin C. Woodle +9 more
TL;DR: The results suggest achievement of two levels of targeting: tumor tissue selective delivery via the nanoparticle ligand and gene pathway selectivity via the siRNA oligonucleotide, opening the door for better targeted therapeutics with both tissue and gene selectivity, also to improve targeted therapies with less than ideal therapeutic targets.
Journal ArticleDOI
Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system
TL;DR: The literature reviewed provides enough promise for anticipating therapeutic and diagnostic applications of surface-modified nanoparticles, with particular focus on the literature concerning particles other than liposomes.
Journal ArticleDOI
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
TL;DR: The combination of chelation or incorporation of imaging moieties and pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release will further improve specificity and efficacy of micelle-based drug delivery.
Journal ArticleDOI
In situ gelling hydrogels for pharmaceutical and biomedical applications.
TL;DR: An overview of in situ gelling systems and their potential in biomedical applications, both photopolymerizable as well as self-assembling hydrogels, based on either chemical crosslinks or physical interactions will be addressed.