Gert Storm

TL;DR: In this article, the authors introduced several mechanisms and agents which are involved in endosomal escape, including pore formation, pH buffering effect of protonable groups and fusion into the lipid bilayer of endosomes.

TL;DR: The results suggest achievement of two levels of targeting: tumor tissue selective delivery via the nanoparticle ligand and gene pathway selectivity via the siRNA oligonucleotide, opening the door for better targeted therapeutics with both tissue and gene selectivity, also to improve targeted therapies with less than ideal therapeutic targets.

TL;DR: The literature reviewed provides enough promise for anticipating therapeutic and diagnostic applications of surface-modified nanoparticles, with particular focus on the literature concerning particles other than liposomes.

TL;DR: The combination of chelation or incorporation of imaging moieties and pH-, thermo-, ultrasound-, or light-sensitive block copolymers allow for controlled micelle dissociation and triggered drug release will further improve specificity and efficacy of micelle-based drug delivery.

TL;DR: An overview of in situ gelling systems and their potential in biomedical applications, both photopolymerizable as well as self-assembling hydrogels, based on either chemical crosslinks or physical interactions will be addressed.