G
Gilles A. Lajoie
Researcher at University of Western Ontario
Publications - 189
Citations - 10294
Gilles A. Lajoie is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Amino acid & Mass spectrometry. The author has an hindex of 45, co-authored 176 publications receiving 9305 citations. Previous affiliations of Gilles A. Lajoie include University of Waterloo & McGill University.
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Journal ArticleDOI
PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry
Bin Ma,Kaizhong Zhang,Christopher Hendrie,Chengzhi Liang,Ming Li,Amanda Doherty-Kirby,Gilles A. Lajoie +6 more
TL;DR: A new de novo sequencing software package, PEAKS, is described, to extract amino acid sequence information without the use of databases, using a new model and a new algorithm to efficiently compute the best peptide sequences whose fragment ions can best interpret the peaks in the MS/MS spectrum.
Journal ArticleDOI
Matrigel: A complex protein mixture required for optimal growth of cell culture
TL;DR: The ability to identify the low mass and abundance components of Matrigel illustrates the utility of this method for the analysis of the extracellular matrix, as well as the complexity of the matrix itself.
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PEAKS DB: De Novo Sequencing Assisted Database Search for Sensitive and Accurate Peptide Identification
Jing Zhang,Lei Xin,Baozhen Shan,Weiwu Chen,Mingjie Xie,Denis Yuen,Weiming Zhang,Zefeng Zhang,Gilles A. Lajoie,Bin Ma +9 more
TL;DR: A new database search tool, PEAKS DB, has been developed by incorporating the de novo sequencing results into the database search, and achieves significantly improved accuracy and sensitivity over two other commonly used software packages.
Journal ArticleDOI
IGF and FGF cooperatively establish the regulatory stem cell niche of pluripotent human cells in vitro
Sean C. Bendall,Morag Stewart,Pablo Menendez,Dustin George,Kausalia Vijayaragavan,Tamra E. Werbowetski-Ogilvie,Verónica Ramos-Mejía,Anne Rouleau,Jiabi Yang,Marc Bossé,Gilles A. Lajoie,Mickie Bhatia +11 more
TL;DR: This study demonstrates a direct role of the IGF-II/IGF1R axis on human ES cell physiology and establishes that hdFs produced by human ES cells themselves define the stem cell niche of pluripotent human stem cells.
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A HUPO test sample study reveals common problems in mass spectrometry–based proteomics
Alexander W. Bell,Eric W. Deutsch,Catherine E. Au,Robert E. Kearney,Ron Beavis,Salvatore Sechi,Tommy Nilsson,John J.M. Bergeron,Thomas A. Beardslee,Thomas Chappell,Gavin Meredith,Peter J. Sheffield,Phillip Gray,Mahbod Hajivandi,Marshall Pope,Paul F. Predki,Majlinda Kullolli,Marina Hincapie,William S. Hancock,Wei Jia,Lina Song,Lei Li,Junying Wei,Bing Yang,Jinglan Wang,Wantao Ying,Yangjun Zhang,Yun Cai,Xiaohong Qian,Fuchu He,Helmut E. Meyer,Christian Stephan,Martin Eisenacher,Katrin Marcus,Elmar Langenfeld,Caroline May,Steve A. Carr,Rushdy Ahmad,Wenhong Zhu,Jeffrey W. Smith,Samir M. Hanash,Jason J. Struthers,Hong Wang,Qing Zhang,Yanming An,Radoslav Goldman,Elisabet Carlsohn,Sjoerd van der Post,Kenneth E. Hung,David A. Sarracino,Kenneth C. Parker,Bryan Krastins,Raju Kucherlapati,Sylvie Bourassa,Guy G. Poirier,Eugene A. Kapp,Heather Patsiouras,Robert L. Moritz,Richard J. Simpson,Benoit Houle,Sylvie Laboissiere,Pavel Metalnikov,Vivian Nguyen,Tony Pawson,Catherine C. L. Wong,Daniel Cociorva,John R. Yates,Michael J. Ellison,Ana Lopez-Campistrous,P. D. Semchuk,Yueju Wang,Peipei Ping,Giuliano Elia,Michael J. Dunn,Kieran Wynne,Angela K. Walker,John R. Strahler,Philip C. Andrews,Brian L. Hood,William L. Bigbee,Thomas P. Conrads,Derek Smith,Christoph H. Borchers,Gilles A. Lajoie,Sean C. Bendall,Kaye D. Speicher,David W. Speicher,Masanori Fujimoto,Kazuyuki Nakamura,Young Ki Paik,Sang Yun Cho,Min-Seok Kwon,Hyoung Joo Lee,Seul Ki Jeong,An Sung Chung,Christine A. Miller,Rudolf Grimm,Katy Williams,Craig A. Dorschel,Jayson A. Falkner,Lennart Martens,Juan Antonio Vizcaíno +101 more
TL;DR: Central analysis determined missed identifications, environmental contamination, database matching and curation of protein identifications as sources of problems in liquid chromatography–mass spectrometry–based proteomics.