G
Giuliano Binetti
Researcher at Sacred Heart Hospital
Publications - 250
Citations - 13455
Giuliano Binetti is an academic researcher from Sacred Heart Hospital. The author has contributed to research in topics: Frontotemporal dementia & Dementia. The author has an hindex of 60, co-authored 234 publications receiving 11295 citations. Previous affiliations of Giuliano Binetti include Massachusetts Institute of Technology.
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Journal ArticleDOI
Role for ATXN1, ATXN2, and HTT intermediate repeats in frontotemporal dementia and Alzheimer's disease.
Irene Rosas,Carmen Martínez,Jordi Clarimón,Alberto Lleó,Ignacio Illán-Gala,Oriol Dols-Icardo,Barbara Borroni,Maria Rosário Almeida,Julie van der Zee,Christine Van Broeckhoven,Amalia C. Bruni,Maria Anfossi,Livia Bernardi,Raffaele Maletta,Maria Serpente,Daniela Galimberti,Elio Scarpini,Giacomina Rossi,Paola Caroppo,Luisa Benussi,Roberta Ghidoni,Giuliano Binetti,Benedetta Nacmias,Sandro Sorbi,Irene Piaceri,Silvia Bagnoli,Anna Antonell,Raquel Sánchez-Valle,Beatriz De la Casa-Fages,Francisco Grandas,Monica Diez-Fairen,Pau Pastor,Raffaele Ferrari,Victoria Alvarez,Manuel Menéndez-González +34 more
TL;DR: It is suggested that the HTT and ATXN1 IAS may contribute to PNFA pathogenesis and point to a link between ATXn2 IAS and AD.
Journal ArticleDOI
Risperidone treatment of behavioral disturbances in outpatients with dementia.
Michael C. Irizarry,S. Nassir Ghaemi,Erica R. Lee-Cherry,Teresa Gomez-Isla,Giuliano Binetti,Bradley T. Hyman,John H. Growdon +6 more
TL;DR: Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but was limited by EPS in about one-third of patients.
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High frequency of mutations in four different disease genes in early-onset dementia.
Ulrich Finckh,Tomas Müller-Thomsen,Ulrike Mann,Christian Eggers,Josef Marksteiner,Wolfgang Meins,Giuliano Binetti,Antonella Alberici,Peter Sonderegger,Christoph Hock,Roger M. Nitsch,Andreas Gal +11 more
TL;DR: Mutation findings may be the most specific biomarkers for an ante mortem diagnosis of FAD or hereditary prion disease.
Journal ArticleDOI
Loss of Neuroprotective Factors in Neurodegenerative Dementias: The End or the Starting Point?
TL;DR: The molecular mechanism underlying the loss of neuroprotective factors in neurodegenerative diseases leading to dementia is reviewed, with a special focus on endo-lysosomal pathway and intercellular communication mediated by extracellular vesicles.
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Bradykinin-induced amyloid precursor protein secretion: a protein kinase C-independent mechanism that is not altered in fibroblasts from patients with sporadic Alzheimer's disease.
TL;DR: The results are the first example of receptor-mediated sAPP release in human skin fibroblasts and the first demonstration of the co-existence of protein kinase C-dependent and -independent mechanisms in these cells.