G
Giuliano Binetti
Researcher at Sacred Heart Hospital
Publications - 250
Citations - 13455
Giuliano Binetti is an academic researcher from Sacred Heart Hospital. The author has contributed to research in topics: Frontotemporal dementia & Dementia. The author has an hindex of 60, co-authored 234 publications receiving 11295 citations. Previous affiliations of Giuliano Binetti include Massachusetts Institute of Technology.
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Journal ArticleDOI
A Window into the Heterogeneity of Human Cerebrospinal Fluid Aβ Peptides
Roberta Ghidoni,Anna Paterlini,Valentina Albertini,Elena Stoppani,Giuliano Binetti,Kjell Fuxe,Luisa Benussi,Luigi F. Agnati +7 more
TL;DR: It is suggested that Aβ peptides as well as other key signals in the central nervous system (CNS), mainly involved in learning and hence plasticity, may have a double-edged sword action on neuron survival and function.
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The level of 24-Hydroxycholesteryl Esters is an Early Marker of Alzheimer's Disease.
Luisa Benussi,Roberta Ghidoni,Fabrizio Dal Piaz,Giuliano Binetti,Giuseppe Di Iorio,Paolo Abrescia +5 more
TL;DR: The reduction of % 24 OH-CE in AD and MCI conv-AD, as well as the anticipation of the disease in patients with the lowest % 24OH-CE, support a role of the cholesterol/lecithin-cholesterol acyltransferase axis in AD onset/progression.
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PRNP P39L Variant is a Rare Cause of Frontotemporal Dementia in Italian Population
Emanuela Oldoni,Giorgio G. Fumagalli,Maria Serpente,Chiara Fenoglio,Marta Scarioni,Andrea Arighi,Giuseppe Bruno,Giuseppina Talarico,Annamaria Confaloni,Paola Piscopo,Benedetta Nacmias,Sandro Sorbi,Innocenzo Rainero,Elisa Rubino,Lorenzo Pinessi,Giuliano Binetti,Roberta Ghidoni,Luisa Benussi,Giulia Grande,Beatrice Arosio,Devan Bursey,John S. K. Kauwe,Sara M G Cioffi,Marina Arcaro,Daniela Mari,Claudio Mariani,Elio Scarpini,Daniela Galimberti +27 more
TL;DR: The missense P39L variant in the prion protein gene (PRNP) has recently been associated with frontotemporal dementia (FTD) and a single carrier among patients is found and may be an extremely rare cause of FTD.
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Estimating the age of the most common Italian GRN mutation: walking back to Canossa times.
Luisa Benussi,Rosa Rademakers,Nicola J. Rutherford,Aleksandra Wojtas,Michela Glionna,Anna Paterlini,Valentina Albertini,Thomas Bettecken,Giuliano Binetti,Roberta Ghidoni +9 more
TL;DR: It is shown that almost all families (30/32) can be traced to a single founder and targeting mutation carriers offers a unique model to test disease-modifying drugs in clinical trials.
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A Transcultural Study of Agitation in Dementia
Jong Ling Fuh,Michael S. Mega,Giuliano Binetti,Shuu Jiun Wang,Eugenio Magni,Jeffrey L. Cummings +5 more
TL;DR: Cultural factors may influence the manifestation of agitation more than a common underlying neuropathology and management strategies targeting unique behavioral instigators of agitation may be specific for different ethnic groups.