Redefining the genetic hierarchies controlling skeletal myogenesis: Pax-3 and Myf-5 act upstream of MyoD.
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TLDR
P Pax-3 and Myf-5 define two distinct myogenic pathways, and MyoD acts genetically downstream of these genes for myogenesis in the body, and this genetic hierarchy does not appear to operate for head muscle formation.About:
This article is published in Cell.The article was published on 1997-04-04 and is currently open access. It has received 834 citations till now. The article focuses on the topics: MYF5 & Myogenin.read more
Citations
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Journal ArticleDOI
Super-Enhancers in the Control of Cell Identity and Disease
Denes Hnisz,Brian J. Abraham,Tong Ihn Lee,Ashley Lau,Violaine Saint-André,Alla A. Sigova,Heather A. Hoke,Richard A. Young +7 more
TL;DR: The super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity and play key roles in human cell identity in health and in disease as mentioned in this paper.
Journal ArticleDOI
Cellular and Molecular Regulation of Muscle Regeneration
TL;DR: Recent evidence supports the possible contribution of adult stem cells in the muscle regeneration process and in particular, bone marrow-derived and muscle-derived stem cells contribute to new myofiber formation and to the satellite cell pool after injury.
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Pax7 is required for the specification of myogenic satellite cells.
Patrick Seale,Luc A. Sabourin,Adele Girgis-Gabardo,Ahmed Mansouri,Peter Gruss,Michael A. Rudnicki +5 more
TL;DR: The paired box transcription factor Pax7 was isolated by representational difference analysis as a gene specifically expressed in cultured satellite cell-derived myoblasts and it was demonstrated that satellite cells and muscle-derived stem cells represent distinct cell populations.
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Myogenic satellite cells: physiology to molecular biology.
Thomas J. Hawke,Daniel J. Garry +1 more
TL;DR: This review will highlight the origin and unique markers of the satellite cell population, the regulation by growth factors, and the response to physiological and pathological stimuli, and identify future research goals for the study of satellite cell biology.
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A Pax3/Pax7-dependent population of skeletal muscle progenitor cells
TL;DR: A new cell population that expresses the transcription factors Pax3 and Pax7 but no skeletal-muscle-specific markers constitutes a source of myogenic cells of prime importance for skeletal muscle formation, a finding also of potential value in the context of cell therapy for muscle disease.
References
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MyoD or Myf-5 is required for the formation of skeletal muscle
Michael A. Rudnicki,Patrick N. J. Schnegelsberg,R. H. Stead,Thomas Braun,Hans-Henning Arnold,Rudolf Jaenisch +5 more
TL;DR: Observations suggest that either Myf-5 or MyoD is required for the determination of skeletal myoblasts, their propagation, or both during embryonic development and indicate that these factors play, at least in part, functionally redundant roles in myogenesis.
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The myoD gene family: nodal point during specification of the muscle cell lineage
Harold Weintraub,Robert B. Davis,Stephen J Tapscott,Matthew Thayer,Michael Krause,Robert Benezra,T. Keith Blackwell,David L. Turner,Ralph A.W. Rupp,Stanley M. Hollenberg,Yuan Zhuang,Andrew Lassar +11 more
TL;DR: The myoD gene converts many differentiated cell types into muscle, and the helix-loop-helix motif is responsible for dimerization, and, depending on itsDimerization partner, MyoD activity can be controlled.
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Simplified mammalian DNA isolation procedure.
TL;DR: This work has simplified the standard mammalian DNA isolation procedure with the aim of minimizing the number of manipulations required for each sample.
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Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene
Paul Hasty,Paul Hasty,Allan Bradley,Julia Hsi Morris,Diane G. Edmondson,Judith M. Venuti,Eric N. Olson,William H. Klein +7 more
TL;DR: To test Myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated and these mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle.
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Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.
TL;DR: It is reported that the c-met-encoded receptor tyrosine kinase is essential for migration of myogenic precursor cells into the limb anlage and for migration into diaphragm and tip of tongue.