G
Gonul Velicelebi
Researcher at Salk Institute for Biological Studies
Publications - 64
Citations - 5999
Gonul Velicelebi is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Receptor & Glutamate receptor. The author has an hindex of 28, co-authored 64 publications receiving 5823 citations. Previous affiliations of Gonul Velicelebi include Conrad Hotels & Torrey Pines Institute for Molecular Studies.
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Journal ArticleDOI
STIM1, an essential and conserved component of store-operated Ca2+ channel function
Jack Roos,Paul J. Digregorio,Andriy V. Yeromin,Kari Lynn Ohlsen,Maria I. Lioudyno,Shenyuan L. Zhang,Olga Safrina,J. Ashot Kozak,Steven L. Wagner,Michael D. Cahalan,Gonul Velicelebi,Kenneth A. Stauderman +11 more
TL;DR: It is proposed that STIM1, a ubiquitously expressed protein that is conserved from Drosophila to mammalian cells, plays an essential role in SOC influx and may be a common component of SOC and CRAC channels.
Journal ArticleDOI
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
Fabrizio Gasparini,Kurt Lingenhöhl,Natacha Stoehr,Peter J. Flor,Micheline Heinrich,Ivo Vranesic,Michel Biollaz,Hans Allgeier,Roland Heckendorn,Stephan Urwyler,Mark A. Varney,Edwin C. Johnson,Stephen D. Hess,Sara P. Rao,Aida I. Sacaan,Emily M. Santori,Gonul Velicelebi,Rainer Kuhn +17 more
TL;DR: 2-methyl-6-(phenylethynyl)-pyridine is described as a potent, selective and systemically active antagonist for the metabotropic glutamate receptor subtype 5 (mGlu5) and in rat neonatal brain slices, MPEP inhibited DHPG-stimulated PI hydrolysis with a potency and selectivity similar to that observed on human mGlu receptors.
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Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype
Mark E. Williams,Daniel H. Feldman,Ann F. McCue,Robert Brenner,Gonul Velicelebi,Steven B. Ellis,Michael M. Harpold +6 more
TL;DR: The alpha 1 subunit directs the recombinant expression of a dihydropyridine-sensitive L-type Ca2+ channel when coexpressed with the beta (beta 2) and the alpha 2 (alpha 2b) subunits in Xenopus oocytes.
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Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel
Mark E. Williams,Paul Brust,Daniel H. Feldman,Saraswathi Patthi,Susan Simerson,Azarnoush Maroufi,Ann F. McCue,Gonul Velicelebi,Steven B. Ellis,Michael M. Harpold +9 more
TL;DR: The heterogeneity of alpha 1B-1 alpha 2b beta 2-transfected cells displayed a single class of saturable, high-affinity (dissociation constant = 55 pM) omega-CgTx binding sites, which are consistent with multiple, biophysically distinct N-type calcium channels.
Journal ArticleDOI
Modulation of γ-Secretase Reduces β-Amyloid Deposition in a Transgenic Mouse Model of Alzheimer's Disease
Maria Z. Kounnas,Anne M. Danks,Soan Cheng,Curtis M. Tyree,Elizabeth J. Ackerman,Xulun Zhang,Kwangwook Ahn,Phuong T. Nguyen,Dan Comer,Long Mao,Chengzhi Yu,David P. M. Pleynet,Paul J. Digregorio,Gonul Velicelebi,Kenneth A. Stauderman,William T. Comer,William C. Mobley,Yue-Ming Li,Sangram S. Sisodia,Rudolph E. Tanzi,Steven L. Wagner +20 more
TL;DR: Over 1200 novel gamma-secretase modulator compounds were synthesized that reduced Abeta(42) levels without inhibiting epsilon-site cleavage of APP and Notch, the generation of the APP and notch intracellular domains, respectively.