Journal ArticleDOI
Structure and functional expression of α1, α2, and β subunits of a novel human neuronal calcium channel subtype
Mark E. Williams,Daniel H. Feldman,Ann F. McCue,Robert Brenner,Gonul Velicelebi,Steven B. Ellis,Michael M. Harpold +6 more
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TLDR
The alpha 1 subunit directs the recombinant expression of a dihydropyridine-sensitive L-type Ca2+ channel when coexpressed with the beta (beta 2) and the alpha 2 (alpha 2b) subunits in Xenopus oocytes.About:
This article is published in Neuron.The article was published on 1992-01-01. It has received 501 citations till now. The article focuses on the topics: R-type calcium channel & Protein subunit.read more
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Structure and regulation of voltage-gated Ca2+ channels.
TL;DR: The distinct structures and patterns of regulation of these three families of Ca(2+) channels provide a flexible array of Ca('s 2+) entry pathways in response to changes in membrane potential and a range of possibilities for regulation of Ca (2+) entry by second messenger pathways and interacting proteins.
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The Novel Anticonvulsant Drug, Gabapentin (Neurontin), Binds to the α2δ Subunit of a Calcium Channel
Nicolas S. Gee,Jason P. Brown,Visaka U.K. Dissanayake,James Offord,Richard J. Thurlow,Geoffrey N. Woodruff +5 more
TL;DR: [3H]Gabapentin is the first pharmacological agent described that interacts with an α subunit of a voltage-dependent Ca channel, and binding activity closely followed the elution of the α sub unit.
Journal ArticleDOI
Structure and function of voltage-gated ion channels.
TL;DR: Experiments reveal that this family of channels is built upon a common structural theme with variations appropriate for functional specialization of each channel type.
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Congenital Deafness and Sinoatrial Node Dysfunction in Mice Lacking Class D L-Type Ca2+ Channels
Josef Platzer,Jutta Engel,Anneliese Schrott-Fischer,K Stephan,Sergio Bova,Howard Y. Chen,Hui Zheng,Jörg Striessnig +7 more
TL;DR: It is concluded that alpha1D can form LTCCs with negative activation thresholds essential for normal auditory function and control of cardiac pacemaker activity.
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P-type calcium channels in rat central and peripheral neurons
TL;DR: The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons but had no effect on identified T-type, L- type, or N-type currents in a variety of central and peripheral neurons.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs
TL;DR: 5'-Noncoding sequences have been compiled from 699 vertebrate mRNAs and GCCA/GCCATGG emerges as the consensus sequence for initiation of translation in vertebrates.
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Multiple types of neuronal calcium channels and their selective modulation
TL;DR: Efforts at classifying multiple types of Ca 2+ channels according to differences in their gating, ionic conductance and pharmacology are summarized.
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Primary structure of the receptor for calcium channel blockers from skeletal muscle
Tsutomu Tanabe,Hiroshi Takeshima,Atsushi Mikami,Veit Flockerzi,Hideo Takahashi,Kenji Kangawa,Masayasu Kojima,Hisayuki Matsuo,Tadaaki Hirose,Shosaku Numa +9 more
TL;DR: Structural and sequence similarities to the voltage-dependent sodium channel suggest that in the transverse tubule membrane of skeletal muscle the dihydropyridine receptor may act both as voltage sensor in excitation-contraction coupling and as a calcium channel.
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Multiple calcium channels and neuronal function
TL;DR: It is shown that neurons have a number of different types of calcium channels, each with their own unique properties and pharmacology, and these calcium channels may be important in the control of different aspects of nerve activity.