G
Graeme Milligan
Researcher at University of Glasgow
Publications - 570
Citations - 32250
Graeme Milligan is an academic researcher from University of Glasgow. The author has contributed to research in topics: Receptor & G protein. The author has an hindex of 88, co-authored 556 publications receiving 30032 citations. Previous affiliations of Graeme Milligan include University of Leicester & Autonomous University of Barcelona.
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Journal ArticleDOI
Identification of a serotonin/glutamate receptor complex implicated in psychosis
Javier González-Maeso,Rosalind L. Ang,Tony Yuen,Pokman Chan,Noelia V. Weisstaub,Juan F. López-Giménez,Mingming Zhou,Yuuya Okawa,Luis F. Callado,Graeme Milligan,Jay A. Gingrich,Marta Filizola,J. Javier Meana,Stuart C. Sealfon +13 more
TL;DR: It is shown that the mGluR2 interacts through specific transmembrane helix domains with the 2AR, a member of an unrelated G-protein-coupled receptor family, to form functional complexes in brain cortex that may be involved in the altered cortical processes of schizophrenia.
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Presynaptic Control of Striatal Glutamatergic Neurotransmission by Adenosine A1–A2A Receptor Heteromers
Francisco Ciruela,Vicent Casadó,Ricardo Gouveia Rodrigues,Rafael Luján,Javier Burgueño,Meritxell Canals,Janusz Borycz,Nelson Rebola,Steven R. Goldberg,Josefa Mallol,Antonio Cortés,Enric I. Canela,Juan F. López-Giménez,Graeme Milligan,Carme Lluís,Rodrigo A. Cunha,Sergi Ferré,Rafael Franco +17 more
TL;DR: It is demonstrated that heteromerization of adenosine A1 receptors and A2A receptors allowsAdenosine to exert a fine-tuning modulation of glutamatergic neurotransmission and that chronic caffeine treatment leads to modifications in the function of the A1R–A2AR heteromer that could underlie the strong tolerance to the psychomotor effects of caffeine.
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G Protein–Coupled Receptor Oligomerization Revisited: Functional and Pharmacological Perspectives
Sergi Ferré,Vicent Casadó,Lakshmi A. Devi,Marta Filizola,Ralf Jockers,Martin J. Lohse,Graeme Milligan,Jean-Philippe Pin,Xavier Guitart +8 more
TL;DR: The functional and pharmacological properties of GPCR oligomers are reviewed and some guidelines for the application of discrete direct screening and high-throughput screening approaches to the discovery of receptor-heteromer selective compounds are provided.
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G Protein-Coupled Receptor Dimerization: Function and Ligand Pharmacology
TL;DR: Key questions that remain to be addressed effectively include the prevalence and relevance of these in native tissues and the implications of heterodimerization for pharmacology and, potentially, for drug design.
Journal ArticleDOI
Heterotrimeric G-proteins: a short history
Graeme Milligan,Evi Kostenis +1 more
TL;DR: The generation of chimeras between different α‐subunits defined the role of different sections of the primary/secondary sequence and crystal structures and cocrystals with interacting proteins have given detailed understanding of their molecular structure and basis of function.