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Guangzhu He
Researcher at University of Hong Kong
Publications - 6
Citations - 5966
Guangzhu He is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Sequence assembly & Gene. The author has an hindex of 6, co-authored 6 publications receiving 5104 citations.
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SOAPdenovo2: an empirically improved memory-efficient short-read de novo assembler
Ruibang Luo,Binghang Liu,Yinlong Xie,Yinlong Xie,Zhenyu Li,Weihua Huang,Jianying Yuan,Guangzhu He,Yanxiang Chen,Qi Pan,Yunjie Liu,Jingbo Tang,Gengxiong Wu,Hao Zhang,Yujian Shi,Yong Liu,Chang Yu,Bo Wang,Yao Lu,Changlei Han,David W. Cheung,Siu-Ming Yiu,Shaoliang Peng,Zhu Xiao-qian,Guangming Liu,Xiangke Liao,Yingrui Li,Huanming Yang,Jian Wang,Tak-Wah Lam,Jun Wang +30 more
TL;DR: This work provides an updated assembly version of the 2008 Asian genome using SOAPdenovo2, a new algorithm design that reduces memory consumption in graph construction, resolves more repeat regions in contig assembly, increases coverage and length in scaffold construction, improves gap closing, and optimizes for large genome.
Journal ArticleDOI
SOAPdenovo-Trans: de novo transcriptome assembly with short RNA-Seq reads
Yinlong Xie,Yinlong Xie,Gengxiong Wu,Jingbo Tang,Ruibang Luo,Jordan Patterson,Shanlin Liu,Weihua Huang,Guangzhu He,Shengchang Gu,Shengkang Li,Xin Zhou,Tak-Wah Lam,Yingrui Li,Xun Xu,Gane Ka-Shu Wong,Jun Wang +16 more
TL;DR: The conclusion is that SOAPdenovo-Trans provides higher contiguity, lower redundancy and faster execution, compared with two other popular transcriptome assemblers.
Posted Content
SOAPdenovo-Trans: De novo transcriptome assembly with short RNA-Seq reads
Yinlong Xie,Yinlong Xie,Gengxiong Wu,Jingbo Tang,Ruibang Luo,Jordan Patterson,Shanlin Liu,Weihua Huang,Guangzhu He,Shengchang Gu,Shengkang Li,Xin Zhou,Tak-Wah Lam,Yingrui Li,Xun Xu,Gane Ka-Shu Wong,Jun Wang +16 more
TL;DR: SOAPdenovo-Trans as mentioned in this paper is a de novo transcriptome assembler designed specifically for RNA-Seq that provides higher contiguity, lower redundancy, and faster execution.
Journal ArticleDOI
Erratum to "SOAPdenovo2: An empirically improved memory-efficient short-read de novo assembler" [GigaScience, (2012), 1, 18]
Ruibang Luo,Binghang Liu,Yinlong Xie,Zhenyu Li,Weihua Huang,Jianying Yuan,Guangzhu He,Yanxiang Chen,Qi Pan,Yunjie Liu,Jingbo Tang,Gengxiong Wu,Hao Zhang,Yujian Shi,Yong Liu,Chang Yu,Bo Wang,Yao Lu,Changlei Han,David W. Cheung,Siu-Ming Yiu,Shaoliang Peng,Zhu Xiao-qian,Guangming Liu,Xiangke Liao,Yingrui Li,Huanming Yang,Jian Wang,Tak-Wah Lam,Jun Wang +29 more
TL;DR: This research presents a novel probabilistic approach to estimating the response of the immune system to laser-spot assisted, 3D image recognition.
Journal ArticleDOI
De novo assembly of a haplotype-resolved human genome
Hongzhi Cao,Honglong Wu,Ruibang Luo,Shujia Huang,Yuhui Sun,Xin Tong,Yinlong Xie,Binghang Liu,Hailong Yang,Hancheng Zheng,Jian Li,Bo Li,Yu Wang,Fang Yang,Peng Sun,Siyang Liu,Peng Gao,Haodong Huang,Sun Jing,Dan Chen,Guangzhu He,Weihua Huang,Zheng Huang,Li Yue,Laurent C. A. M. Tellier,Xiao Liu,Qiang Feng,Xun Xu,Xiuqing Zhang,Lars Bolund,Anders Krogh,Karsten Kristiansen,Radoje Drmanac,Snezana Drmanac,Rasmus Nielsen,Songgang Li,Jian Wang,Huanming Yang,Yingrui Li,Gane Ka-Shu Wong,Jun Wang +40 more
TL;DR: This haplotype-resolved diploid genome represents the most complete de novo human genome assembly to date and should aid in translating genotypes to phenotypes for the development of personalized medicine.