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Shujia Huang
Researcher at South China University of Technology
Publications - 25
Citations - 1395
Shujia Huang is an academic researcher from South China University of Technology. The author has contributed to research in topics: Population & Genome. The author has an hindex of 13, co-authored 21 publications receiving 1090 citations. Previous affiliations of Shujia Huang include Beijing Genomics Institute.
Papers
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Journal ArticleDOI
Genomic Analyses from Non-invasive Prenatal Testing Reveal Genetic Associations, Patterns of Viral Infections, and Chinese Population History
Siyang Liu,Shujia Huang,Fang Chen,Lijian Zhao,Yuying Yuan,Stephen S. Francis,Stephen S. Francis,Lin Fang,Zilong Li,Long Lin,Rong Liu,Yong Zhang,Huixin Xu,Shengkang Li,Yuwen Zhou,Robert W. Davies,Qiang Liu,Robin G. Walters,Kuang Lin,Jia Ju,Thorfinn Sand Korneliussen,Melinda A. Yang,Qiaomei Fu,Jun Wang,Lijun Zhou,Anders Krogh,Hongyun Zhang,Wei Wang,Zhengming Chen,Zhiming Cai,Ye Yin,Huanming Yang,Mao Mao,Jay Shendure,Jay Shendure,Jian Wang,Anders Albrechtsen,Xin Jin,Rasmus Nielsen,Rasmus Nielsen,Xun Xu +40 more
TL;DR: It is shown that the present day distribution of alleles is a function of both ancient migration and very recent population movements, and a unique pattern of circulating viral DNA in plasma with high prevalence of hepatitis B and other clinically relevant maternal infections is identified.
Journal ArticleDOI
Novel variation and de novo mutation rates in population-wide de novo assembled Danish trios
Søren Besenbacher,Siyang Liu,Jose M. G. Izarzugaza,Jakob Grove,Kirstine Belling,Jette Bork-Jensen,Shujia Huang,Thomas Damm Als,Shengting Li,Rachita Yadav,Arcadio Rubio-García,Francesco Lescai,Ditte Demontis,J. S. Rao,Weijian Ye,Thomas Mailund,Rune Møllegaard Friborg,Christian N. S. Pedersen,Ruiqi Xu,Jihua Sun,Hao Liu,Ou Wang,Xiaofang Cheng,David Flores,Emil Karol Rydza,Kristoffer Rapacki,John Damm Sørensen,Piotr Jaroslaw Chmura,David Westergaard,Piotr Dworzynski,Thorkild I. A. Sørensen,Ole Lund,Torben Hansen,Xun Xu,Ning Li,Lars Bolund,Oluf Pedersen,Hans Eiberg,Anders Krogh,Anders D. Børglum,Søren Brunak,Karsten Kristiansen,Mikkel H. Schierup,Jun-Jun Wang,Ramneek Gupta,Palle Villesen,Simon Rasmussen +46 more
TL;DR: A Danish pan-genome obtained from sequencing 10 trios to high depth is reported and a higher proportion of indels and SVs are identified than previous efforts showing the merits of high coverage and de novo assembly approaches.
Journal ArticleDOI
Rapid detection of structural variation in a human genome using nanochannel-based genome mapping technology
Hongzhi Cao,Alex Hastie,Dandan Cao,Ernest T. Lam,Yuhui Sun,Haodong Huang,Xiao Liu,Liya Lin,Warren Andrews,Saki Chan,Shujia Huang,Xin Tong,Michael Requa,Thomas Anantharaman,Anders Krogh,Huanming Yang,Han Cao,Xun Xu +17 more
TL;DR: This study highlights genome mapping technology as a comprehensive and cost-effective method for detecting structural variation and studying complex regions in the human genome, as well as deciphering viral integration into the host genome.
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An atlas of DNA methylomes in porcine adipose and muscle tissues
Mingzhou Li,Honglong Wu,Zonggang Luo,Zonggang Luo,Yudong Xia,Jiuqiang Guan,Tao Wang,Yiren Gu,Lei Chen,Kai Zhang,Jideng Ma,Yingkai Liu,Zhijun Zhong,Jing Nie,Shuling Zhou,Zhiping Mu,Xiaoyan Wang,Jingjing Qu,Long Jing,Huiyu Wang,Shujia Huang,Na Yi,Zhe Wang,Dongxing Xi,Juan Wang,Guangliang Yin,Li Wang,Ning Li,Zhi Jiang,Qiulei Lang,Huasheng Xiao,Anan Jiang,Li Zhu,Yanzhi Jiang,Guoqing Tang,Miaomiao Mai,Surong Shuai,Kui Li,Jinyong Wang,Xiuqing Zhang,Yingrui Li,Haosi Chen,Xiaolian Gao,Graham Plastow,Stephen Beck,Huanming Yang,Jian Wang,Jun Wang,Xuewei Li,Ruiqiang Li +49 more
TL;DR: This comprehensive map provides a solid basis for exploring the epigenetic mechanisms of adipose deposition and muscle growth in pig as a model and identifies the differentially methylated regions in promoters.
Journal ArticleDOI
Initial whole-genome sequencing and analysis of the host genetic contribution to COVID-19 severity and susceptibility
Fang Wang,Shujia Huang,Rongsui Gao,Yuwen Zhou,Changxiang Lai,Zhichao Li,Wenjie Xian,Xiaobo Qian,Zhiyu Li,Yushan Huang,Qiyuan Tang,Panhong Liu,Ruikun Chen,Rong Liu,Xuan Li,Xin Tong,Xuan Zhou,Yong Bai,Gang Duan,Tao Zhang,Xun Xu,Jian Wang,Huanming Yang,Siyang Liu,Qing He,Xin Jin,Lei Liu +26 more
TL;DR: This initial genomic study of Chinese patients provides genetic insights into the phenotypic difference among the COVID-19 patient groups and highlighted genes and variants that may help guide targeted efforts in containing the outbreak.