Angelina S. Gross

TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.

TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.

TL;DR: The protective capacity of the natural autophagy inducer spermidine was tested in animal models of aging and hypertension, which both represent major risk factors for the development of cardiovascular disease.

TL;DR: The current mechanistic understanding of how cells regulate the initiation of macroautophagy to target substrates nonselectively or selectively is outlined and the emerging principles underlying the regulation of autophagy substrate recognition are described.

TL;DR: It is shown that in aging yeast, autophagy levels highly depend on the activity of Acetyl-CoA carboxylase 1, and proposed Acc1-dependent lipogenesis as a fundamental metabolic path downstream of Snf1 to maintainAutophagy and survival during cellular aging.