Amit Kumar

TL;DR: TF viruses are enriched for higher Env content, enhanced cell-free infectivity, improved dendritic cell interaction, and relative IFN-α resistance, which should be considered in the development and testing of AIDS vaccines.

TL;DR: The development of a VH1-46-derived antibody lineage that matured to neutralize 90% of HIV-1 isolates is defined with longitudinal sampling from time-of-infection to suggest a vaccination strategy for inducing both lineages.

TL;DR: The B cell response in a bnAb-producing individual is studied and two B cell lineages cooperated to induce the development of bnAbs, a virus-neutralizing antibody lineage that targeted an envelope region (loop D) and selected virus escape mutants that resulted in both enhanced B cell lineage envelope binding and escape mutant neutralization-traits associated with increased B cell antigen drive.

TL;DR: It is found that T/F and chronic control Envs were indistinguishable in the efficiency with which they used CD4 and CCR5, and saturating concentrations of anti-α4β7 antibodies failed to inhibit infection and replication of T/f as well as chronic control viruses.

TL;DR: For one of these mAbs, gp41 mAb 7B2, this work provides the first co-crystal structure in complex with a common cyclical loop motif demonstrated to be critical for infection by other retroviruses.