Haitian Zhao

TL;DR: A proteasome-dependent anti-amyloidogenic activity of resveratrol is demonstrated and it is suggested that this natural compound has a therapeutic potential in Alzheimer's disease.

TL;DR: It is shown that AMPK signaling controls Aβ metabolism and mediates the anti-amyloidogenic effect of resveratrol in non-neuronal and neuronal cells, including in mouse primary neurons, and that resver atrol and pharmacological activation of AMPK have therapeutic potential against Alzheimer disease.

TL;DR: The authors showed that resveratrol, a natural polyphenol associated with anti-inflammatory effects and currently in clinical trials for AD, prevented the activation of macrophages and microglial BV-2 cells treated with TLR4 ligand, lipopolysaccharide (LPS).

TL;DR: It is proposed that CALHM1 encodes an essential component of a previously uncharacterized cerebral Ca(2+) channel that controls Abeta levels and susceptibility to late-onset AD.

TL;DR: In vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases, and shed light on the molecular mechanisms potentially involved in the beneficial effects of resver atrol intake against the neurodegenerative process in Alzheimer's disease.