Hao Tang

TL;DR: It is reported here that the intracellular domain of Robo interacts with a novel family of Rho GTPase activating proteins (GAPs) that are expressed in regions responsive to Slit and demonstrated important roles for GAPs and Cdc42 in neuronal migration.

TL;DR: It is reported that Slit, a secreted protein previously known for its role of repulsion in axon guidance and neuronal migration, can also inhibit leukocyte chemotaxis induced by chemotactic factors, and a new therapeutic approach is proposed to treat diseases involving leukocytes andChemotactic Factors.

TL;DR: The results show the biochemical and functional links between netrin, a prototypical neuronal guidance cue, and FAK, a central player in intracellular signaling that is crucial for cell migration.

TL;DR: The results implicate the human tau gene as a target gene for the alternative splicing regulator Tra2 β, suggesting that Tra2β may play a role in aberrant tau exon 10 alternativesplicing and in the pathogenesis of tauopathies.

TL;DR: It is shown that Slit2, a neuronal repellent factor, is up-regulated in the skin by allergen sensitization and down-regulates the migration of Langerhans cells in a manner that results in suppression of contact hypersensitivity responses.