H
Harikrishna Batchu
Researcher at Central Drug Research Institute
Publications - 14
Citations - 259
Harikrishna Batchu is an academic researcher from Central Drug Research Institute. The author has contributed to research in topics: Intramolecular force & Chemistry. The author has an hindex of 7, co-authored 12 publications receiving 228 citations.
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Journal ArticleDOI
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.
Alice E. Williamson,Paul M. Ylioja,Murray N. Robertson,Murray N. Robertson,Yevgeniya Antonova-Koch,Vicky M. Avery,Jonathan B. Baell,Harikrishna Batchu,Sanjay Batra,Jeremy N. Burrows,Soumya Bhattacharyya,Félix Calderón,Susan A. Charman,Julie Clark,Benigno Crespo,Matin Dean,Stefan L. Debbert,Michael J. Delves,Adelaide S. M. Dennis,Frederik Deroose,Sandra Duffy,Sabine Fletcher,Guri Giaever,Irene Hallyburton,Francisco-Javier Gamo,Marinella Gebbia,R. Kiplin Guy,Zoe Hungerford,Kiaran Kirk,Maria J. Lafuente-Monasterio,Anna Lee,Stephan Meister,Corey Nislow,John P. Overington,George Papadatos,Luc Patiny,James Pham,Stuart A. Ralph,Andrea Ruecker,Eileen Ryan,Christopher Southan,Kumkum Srivastava,Chris Swain,Matthew J. Tarnowski,Patrick Thomson,Peter Turner,Iain M. Wallace,Timothy N. C. Wells,Karen L. White,Laura White,Paul Willis,Elizabeth A. Winzeler,Sergio Wittlin,Matthew H. Todd +53 more
TL;DR: One chemical subseries was found to exhibit oral activity but contained a labile ester that could not be replaced without loss of activity, and the original hit exhibited remarkable sensitivity to minor structural change.
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Iodine-Mediated Intramolecular Electrophilic Aromatic Cyclization in Allylamines: A General Route to Synthesis of Quinolines, Pyrazolo[4,3-b]pyridines, and Thieno[3,2-b]pyridines
TL;DR: An unprecedented synthesis of aromatic ring annulated pyridines from suitably substituted primary allylamines via intramolecular electrophilic aromatic cyclization mediated by molecular iodine under mild conditions is described.
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Palladium-Catalyzed Chelation-Assisted Regioselective Oxidative Dehydrogenative Homocoupling/Ortho-Hydroxylation in N-Phenylpyrazoles
TL;DR: It was discovered that if the reactions were performed under highly dilute conditions (ca. 10 times) then N-(o-hydroxyphenyl)pyrazoles were the major or the sole products.
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Straightforward copper-catalyzed synthesis of pyrrolopyrazoles from halogenated pyrazolecarbaldehydes☆
TL;DR: In this paper, a cascade reaction between halopyrazole carbaldehydes and ethylisocyanoacetate in the presence of copper and a base is described.
Journal ArticleDOI
Versatile Synthesis of 2-(Substituted phenyl)-6,7-dihydro-1H-indol-4(5H)-ones from Morita–Baylis–Hillman Acetates of 2-Oxo-2-(substituted phenyl)acetaldehyde
Harikrishna Batchu,Sanjay Batra +1 more
TL;DR: In this article, a versatile synthesis of 2-(substituted phenyl)-6,7-dihydro-1H-indol-4(5H)-ones from adducts of the Morita-Baylis-Hillman reaction between 2-oxo-2-acetaldehydes and cyclohex-2enone under mild conditions is described.