A
Andrea Ruecker
Researcher at Imperial College London
Publications - 32
Citations - 2943
Andrea Ruecker is an academic researcher from Imperial College London. The author has contributed to research in topics: Plasmodium falciparum & Gametocyte. The author has an hindex of 20, co-authored 31 publications receiving 2433 citations. Previous affiliations of Andrea Ruecker include Mahidol University & National Institute for Medical Research.
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Journal ArticleDOI
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
Wesley C. Van Voorhis,John H. Adams,Roberto Adelfio,Roberto Adelfio,Vida Ahyong,Myles H. Akabas,Pietro Alano,Aintzane Alday,Yesmalie Alemán Resto,Aishah Alsibaee,Ainhoa Alzualde,Katherine T. Andrews,Katherine T. Andrews,Simon V. Avery,Vicky M. Avery,Lawrence Ayong,Mark Baker,Stephen Baker,Stephen Baker,Choukri Ben Mamoun,Sangeeta N. Bhatia,Quentin D. Bickle,Lotfi Bounaadja,Tana Bowling,Jürgen Bosch,Lauren E. Boucher,Fabrice Fekam Boyom,José Brea,Marian P. Brennan,Audrey Burton,Conor R. Caffrey,Grazia Camarda,Manuela Carrasquilla,Manuela Carrasquilla,Dee A. Carter,Maria B. Cassera,Ken Chih-Chien Cheng,Worathad Chindaudomsate,Anthony J. Chubb,Beatrice L. Colon,Daisy D. Colón-López,Yolanda Corbett,Gregory J. Crowther,Noemi Cowan,Noemi Cowan,Sarah D'Alessandro,Na Le Dang,Michael J. Delves,Joseph L. DeRisi,Alan Y. Du,Sandra Duffy,Shimaa Abd El-Salam El-Sayed,Shimaa Abd El-Salam El-Sayed,Michael T. Ferdig,José A. Fernández Robledo,David A. Fidock,Isabelle Florent,Patrick Valere Tsouh Fokou,Ani Galstian,Francisco-Javier Gamo,Suzanne Gokool,Ben Gold,Todd R. Golub,Gregory M. Goldgof,Rajarshi Guha,W. Armand Guiguemde,Nil Gural,R. Kiplin Guy,Michael Adsetts Edberg Hansen,Kirsten K. Hanson,Kirsten K. Hanson,Andrew Hemphill,Rob Hooft van Huijsduijnen,Takaaki Horii,Paul Horrocks,Tyler B. Hughes,Christopher D. Huston,Ikuo Igarashi,Katrin Ingram-Sieber,Katrin Ingram-Sieber,Maurice A. Itoe,Ajit Jadhav,Amornrat Naranuntarat Jensen,Laran T. Jensen,Rays H. Y. Jiang,Annette Kaiser,Jennifer Keiser,Jennifer Keiser,Thomas J. Ketas,Sébastien Kicka,Sunyoung Kim,Kiaran Kirk,Vidya Prasanna Kumar,Dennis E. Kyle,Maria Jose Lafuente,Scott M. Landfear,Nathan Lee,Sukjun Lee,Adele M. Lehane,Fengwu Li,David Little,Liqiong Liu,Manuel Llinás,María Isabel Loza,Aristea Lubar,Leonardo Lucantoni,Isabelle S Lucet,Louis Maes,Dalu Mancama,Nuha R. Mansour,Sandra March,Sheena McGowan,Iset Medina Vera,Stephan Meister,Luke Mercer,Jordi Mestres,Alvine Ngoutane Mfopa,Raj N. Misra,Seunghyun Moon,John P. Moore,Francielly Morais Rodrigues da Costa,Joachim Müller,Arantza Muriana,Stephen N. Hewitt,Bakela Nare,Carl Nathan,Nathalie Narraidoo,Sujeevi Nawaratna,Sujeevi Nawaratna,Kayode K. Ojo,Diana Ortiz,Gordana Panic,Gordana Panic,George Papadatos,Silvia Parapini,Kailash P. Patra,Ngoc Minh Pham,Sarah Prats,David Plouffe,Sally-Ann Poulsen,Anupam Pradhan,Celia Quevedo,Ronald J. Quinn,Christopher A. Rice,Mohamed Abdo Rizk,Mohamed Abdo Rizk,Andrea Ruecker,Robert P. St.Onge,Rafaela Salgado Ferreira,Jasmeet Samra,Natalie G. Robinett,Natalie G. Robinett,Ulrich Schlecht,Marjorie Schmitt,Filipe Silva Villela,Francesco Silvestrini,Robert E. Sinden,Dennis A. Smith,Thierry Soldati,Andreas Spitzmüller,Serge Maximilian Stamm,David J. Sullivan,William J. Sullivan,Sundari Suresh,Brian M. Suzuki,Yo Suzuki,S. Joshua Swamidass,Donatella Taramelli,Lauve R. Y. Tchokouaha,Anjo Theron,David Thomas,Kathryn F. Tonissen,Simon Townson,Abhai K. Tripathi,Valentin Trofimov,Kenneth O. Udenze,Imran Ullah,Cindy Vallières,Edgar Vigil,Joseph M. Vinetz,Phat Voong Vinh,Hoan Vu,Nao Aki Watanabe,Kate Weatherby,Pamela M. White,Andrew F. Wilks,Andrew F. Wilks,Elizabeth A. Winzeler,Edward J. Wojcik,Melanie Wree,Wesley Wu,Naoaki Yokoyama,Paul Henri Amvam Zollo,Nada Abla,Benjamin Blasco,Jeremy N. Burrows,Benoît Laleu,Didier Leroy,Thomas Spangenberg,Timothy N. C. Wells,Paul Willis +200 more
TL;DR: The results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications.
Journal ArticleDOI
A novel multiple-stage antimalarial agent that inhibits protein synthesis
Beatriz Baragaña,Irene Hallyburton,Marcus C. S. Lee,Marcus C. S. Lee,Neil R. Norcross,Raffaella Grimaldi,Thomas D. Otto,William R. Proto,Andrew M. Blagborough,Stephan Meister,Grennady Wirjanata,Andrea Ruecker,Leanna M. Upton,Tara S. Abraham,Mariana Justino de Almeida,Anupam Pradhan,Achim Porzelle,María Santos Martínez,Judith M. Bolscher,Andrew Woodland,Suzanne Norval,Fabio Zuccotto,John Thomas,Frederick R. C. Simeons,Laste Stojanovski,Maria Osuna-Cabello,Patrick M. Brock,Thomas S. Churcher,Katarzyna A. Sala,Sara E. Zakutansky,María Belén Jiménez-Díaz,Laura M. Sanz,Jennifer Riley,Rajshekhar Basak,Michael Campbell,Vicky M. Avery,Robert W. Sauerwein,Koen J. Dechering,Rintis Noviyanti,Brice Campo,Julie A. Frearson,Iñigo Angulo-Barturen,Santiago Ferrer-Bazaga,Francisco-Javier Gamo,Paul G. Wyatt,Didier Leroy,Peter Siegl,Michael J. Delves,Dennis E. Kyle,Sergio Wittlin,Jutta Marfurt,Ric N. Price,Robert E. Sinden,Elizabeth A. Winzeler,Susan A. Charman,Lidiya Bebrevska,David W. Gray,Simon Campbell,Alan H. Fairlamb,Paul Willis,Julian C. Rayner,David A. Fidock,Kevin D. Read,Ian H. Gilbert +63 more
TL;DR: DDD107498 was developed from a screening programme against blood-stage malaria parasites and its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis.
Journal ArticleDOI
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
Margaret A. Phillips,Julie Lotharius,Kennan C. Marsh,John H. White,Anthony Dayan,Karen L. White,Jacqueline W. Njoroge,Farah El Mazouni,Yanbin Lao,Sreekanth Kokkonda,Diana R. Tomchick,Xiaoyi Deng,Trevor Laird,Sangeeta N. Bhatia,Sandra March,Caroline L. Ng,David A. Fidock,Sergio Wittlin,Sergio Wittlin,Maria J. Lafuente-Monasterio,Francisco Javier Gamo Benito,Laura Maria Sanz Alonso,María Santos Martínez,María Belén Jiménez-Díaz,Santiago Ferrer Bazaga,Iñigo Angulo-Barturen,John N. Haselden,James B. Louttit,Yi Cui,Arun Sridhar,Anna Marie Zeeman,Clemens H. M. Kocken,Robert W. Sauerwein,Koen J. Dechering,Vicky M. Avery,Sandra Duffy,Michael J. Delves,Robert E. Sinden,Andrea Ruecker,Kristina S. Wickham,Rosemary Rochford,Janet Gahagen,Lalitha V. Iyer,Ed Riccio,Jon C. Mirsalis,Ian Bathhurst,Thomas Rueckle,Xavier C. Ding,Brice Campo,Didier Leroy,M. John Rogers,Pradipsinh K. Rathod,Jeremy N. Burrows,Susan A. Charman +53 more
TL;DR: DSM265, a triazolopyrimidine-based inhibitor of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH), is the first DHODH inhibitor to reach clinical development for treatment of malaria as discussed by the authors.
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Wesley C. Van Voorhis,John H. Adams,Roberto Adelfio,Vida Ahyong,Myles H. Akabas,Pietro Alano,Aintzane Alday,Alemán Resto Yesmalie,Aishah Alsibaee,Ainhoa Alzualde,Katherine T. Andrews,Simon V. Avery,Vicky M. Avery,Lawrence Ayong,Mark Baker,Stephen Baker,Choukri Ben Mamoun,Quentin D. Bickle,Lotfi Bounaadja,Tana Bowling,Jürgen Bosch,Lauren E. Boucher,Fabrice Fekam Boyom,José Brea,Marian P. Brennan,Audrey Burton,Conor R. Caffrey,Grazia Camarda,Manuela Carrasquilla,Dee A. Carter,Maria B. Cassera,Chih-Chien Cheng Ken,Worathad Chindaudomsate,Anthony J. Chubb,Beatrice L. Colon,Daisy D. Colón-López,Yolanda Corbett,Gregory J. Crowther,Noemi Cowan,Sarah D'Alessandro,Na Le Dang,Michael J. Delves,Joseph L. DeRisi,Alan Y. Du,Sandra Duffy,Shimaa Abd El-Salam El-Sayed,Michael T. Ferdig,José A. Fernández Robledo,David A. Fidock,Isabelle Florent,Patrick Valere Tsouh Fokou,Ani Galstian,Francisco-Javier Gamo,Suzanne Gokool,Ben Gold,Todd R. Golub,Gregory M. Goldgof,Rajarshi Guha,W. Armand Guiguemde,Nil Gural,R. Kiplin Guy,Michael Adsetts Edberg Hansen,Kirsten K. Hanson,Andrew Hemphill,Rob Hooft van Huijsduijnen,Takaaki Horii,Paul Horrocks,Tyler B. Hughes,Christopher D. Huston,Ikuo Igarashi,Katrin Ingram-Sieber,Maurice A. Itoe,Ajit Jadhav,Amornrat Naranuntarat Jensen,Laran T. Jensen,Rays H. Y. Jiang,Annette Kaiser,Jennifer Keiser,Thomas J. Ketas,Sébastien Kicka,Sunyoung Kim,Kiaran Kirk,Vidya Prasanna Kumar,Dennis E. Kyle,Maria Jose Lafuente,Scott M. Landfear,Nathan Lee,Sukjun Lee,Adele M. Lehane,Fengwu Li,David Little,Liqiong Liu,Manuel Llinás,María Isabel Loza,Aristea Lubar,Leonardo Lucantoni,Isabelle S Lucet,Louis Maes,Dalu Mancama,Nuha R. Mansour,Sandra March,Sheena McGowan,Iset Medina Vera,Stephan Meister,Luke Mercer,Jordi Mestres,Alvine Ngoutane Mfopa,Raj N. Misra,Seung-Hyun Moon,John P. Moore,Francielly Morais Rodrigues da Costa,Joachim Müller,Arantza Muriana,Stephen N. Hewitt,Bakela Nare,Carl Nathan,Nathalie Narraidoo,Sujeevi Nawaratna,Kayode K. Ojo,Diana Ortiz,Gordana Panic,George Papadatos,Silvia Parapini,Kailash P. Patra,Ngoc Minh Pham,Sarah Prats,David Plouffe,Sally-Ann Poulsen,Anupam Pradhan,Celia Quevedo,Ronald J. Quinn,Christopher A. Rice,Andrea Ruecker,Robert P. St.Onge,Rafaela Salgado Ferreira,Jasmeet Samra,Natalie G. Robinett,Ulrich Schlecht,Marjorie Schmitt,Filipe Silva Villela,Francesco Silvestrini,Robert E. Sinden,Dennis A. Smith,Thierry Soldati,Andreas Spitzmüller,Serge Maximilian Stamm,David J. Sullivan,William J. Sullivan,Sundari Suresh,Brian M. Suzuki,Yo Suzuki,S. Joshua Swamidass,Donatella Taramelli,Lauve R. Y. Tchokouaha,Anjo Theron,David Thomas,Kathryn F. Tonissen,Simon Townson,Abhai K. Tripathi,Valentin Trofimov,Kenneth O. Udenze,Imran Ullah,Cindy Vallières,Edgar Vigil,Joseph M. Vinetz,Phat Voong Vinh,Hoan Vu,Nao-aki Watanabe,Kate Weatherby,Pamela M. White,Andrew F. Wilks,Elizabeth A. Winzeler,Edward J. Wojcik,Melanie Wree,Wesley Wu,Naoaki Yokoyama,Paul Henri Amvam Zollo,Nada Abla,Benjamin Blasco,Jeremy N. Burrows,Benoît Laleu,Didier Leroy,Thomas Spangenberg,Timothy N. C. Wells,Paul Willis,Sangeeta N. Bhatia +185 more
TL;DR: The Medicines for Malaria Venture Malaria Box as mentioned in this paper is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite.
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
Margaret A. Phillips,Julie Lotharius,Kennan C. Marsh,John H. White,A. Dayan,Karen L. White,Jacqueline W. Njoroge,F. El Mazouni,Y. Lao,Sreekanth Kokkonda,Diana R. Tomchick,Xiaoyi Deng,T. Laird,Caroline L. Ng,David A. Fidock,Sergio Wittlin,Maria Jose Lafuente-Monasterio,Francisco Javier Gamo Benito,L. M. S. Alonso,María Santos Martínez,María-Belén Jiménez-Díaz,Santiago Ferrer Bazaga,Iñigo Angulo-Barturen,John N. Haselden,James B. Louttit,Yi Cui,Arun Sridhar,Anne-Marie Zeeman,Clemens H. M. Kocken,Robert W. Sauerwein,Koen J. Dechering,Vicky M. Avery,Sandra Duffy,Michael J. Delves,Robert E. Sinden,Andrea Ruecker,Kristina S. Wickham,Rosemary Rochford,Janet Gahagen,Lalitha V. Iyer,Ed Riccio,Jon C. Mirsalis,I. Bathhurst,Thomas Rueckle,Xavier C. Ding,Brice Campo,Didier Leroy,M. J. Rogers,Pradipsinh K. Rathod,Jeremy N. Burrows,Susan A. Charman,Sangeeta N. Bhatia,Sandra March-Riera +52 more
TL;DR: The excellent safety profile, blood- and liver-stage activity, and predicted long half-life in humans position DSM265 as a new potential drug combination partner for either single-dose treatment or once-weekly chemoprevention of malaria.