M
Murray N. Robertson
Researcher at Strathclyde Institute of Pharmacy and Biomedical Sciences
Publications - 20
Citations - 568
Murray N. Robertson is an academic researcher from Strathclyde Institute of Pharmacy and Biomedical Sciences. The author has contributed to research in topics: Binding site & In vivo. The author has an hindex of 13, co-authored 20 publications receiving 466 citations. Previous affiliations of Murray N. Robertson include University of Strathclyde & University of Sydney.
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Journal ArticleDOI
Activity of Praziquantel Enantiomers and Main Metabolites against Schistosoma mansoni
Isabel Meister,Katrin Ingram-Sieber,Katrin Ingram-Sieber,Noemi Cowan,Noemi Cowan,Matthew H. Todd,Murray N. Robertson,Claudia Meli,Malay Patra,Gilles Gasser,Jennifer Keiser +10 more
TL;DR: Investigation of the in vitro activities of PZQ and its main metabolites confirmed that R-PZQ is the main effector molecule, while S-PzQ and the metabolites do not play a significant role in the antischistosomal properties of PzQ.
Journal ArticleDOI
Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles.
Alice E. Williamson,Paul M. Ylioja,Murray N. Robertson,Murray N. Robertson,Yevgeniya Antonova-Koch,Vicky M. Avery,Jonathan B. Baell,Harikrishna Batchu,Sanjay Batra,Jeremy N. Burrows,Soumya Bhattacharyya,Félix Calderón,Susan A. Charman,Julie Clark,Benigno Crespo,Matin Dean,Stefan L. Debbert,Michael J. Delves,Adelaide S. M. Dennis,Frederik Deroose,Sandra Duffy,Sabine Fletcher,Guri Giaever,Irene Hallyburton,Francisco-Javier Gamo,Marinella Gebbia,R. Kiplin Guy,Zoe Hungerford,Kiaran Kirk,Maria J. Lafuente-Monasterio,Anna Lee,Stephan Meister,Corey Nislow,John P. Overington,George Papadatos,Luc Patiny,James Pham,Stuart A. Ralph,Andrea Ruecker,Eileen Ryan,Christopher Southan,Kumkum Srivastava,Chris Swain,Matthew J. Tarnowski,Patrick Thomson,Peter Turner,Iain M. Wallace,Timothy N. C. Wells,Karen L. White,Laura White,Paul Willis,Elizabeth A. Winzeler,Sergio Wittlin,Matthew H. Todd +53 more
TL;DR: One chemical subseries was found to exhibit oral activity but contained a labile ester that could not be replaced without loss of activity, and the original hit exhibited remarkable sensitivity to minor structural change.
Journal ArticleDOI
Enabling precision manufacturing of active pharmaceutical ingredients: workflow for seeded cooling continuous crystallisations
Cameron J. Brown,Thomas McGlone,Stephanie Yerdelen,Vijay Srirambhatla,Fraser Adam Mabbott,Rajesh Gurung,Maria L. Briuglia,Bilal Ahmed,Hector Polyzois,John McGinty,Francesca Perciballi,Dimitrios Fysikopoulos,Pól MacFhionnghaile,Humera Siddique,Vishal Raval,Tomás Seosamh Harrington,Antony D. Vassileiou,Murray N. Robertson,Elke Prasad,Andrea Johnston,Blair F. Johnston,Alison Nordon,Jagjit Singh Srai,Gavin Halbert,Joop H. ter Horst,Chris John Price,Chris D. Rielly,Jan Sefcik,Alastair J. Florence +28 more
TL;DR: In this paper, an innovative system-wide approach to decision making has been developed to support rapid, systematic, and efficient continuous seeded cooling crystallization process design, where the goal is to develop and operate a robust, consistent process with tight control of particle attributes.
Journal ArticleDOI
Open source drug discovery – A limited tutorial
Murray N. Robertson,Paul M. Ylioja,Alice E. Williamson,Michael Woelfle,Michael Robins,Katrina A. Badiola,Paul Willis,Piero Olliaro,Timothy N. C. Wells,Matthew H. Todd +9 more
TL;DR: Some straightforward steps others may wish to take towards more openness in their own research programmes are described, while existing and inexpensive online tools can solve many challenges.
Journal ArticleDOI
In vitro metabolic profile and in vivo antischistosomal activity studies of (η(6)-praziquantel)Cr(CO)3 derivatives.
Malay Patra,Katrin Ingram,Anna Leonidova,Vanessa Pierroz,Stefano Ferrari,Murray N. Robertson,Matthew H. Todd,Jennifer Keiser,Gilles Gasser +8 more
TL;DR: In vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel with the formula (η(6)-PZQ)Cr(CO)3 (1 and 2), by use of human liver microsomes, where the R-enantiomers are highly active against adult schistosomes in vitro, whereas both S- enantiomers lack activity.