H
Heather A. Sullivan
Researcher at Massachusetts Institute of Technology
Publications - 13
Citations - 1473
Heather A. Sullivan is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Biology & Rabies virus. The author has an hindex of 8, co-authored 8 publications receiving 1004 citations.
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Journal ArticleDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Lucas T. Graybuck,Kimberly A. Smith,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Sheana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Heather A. Sullivan,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +48 more
TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.
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Production of glycoprotein-deleted rabies viruses for monosynaptic tracing and high-level gene expression in neurons
TL;DR: In this article, a detailed protocol for the production of high-titer and high-purity viral stocks, from initial generation of infectious virus from cDNA through amplification on complementing cell lines, pseudotyping if desired, purification by ultracentrifugation and titering, requires 3-4 weeks to complete.
Journal ArticleDOI
Axonal and subcellular labelling using modified rabies viral vectors
TL;DR: It is shown that deletion-mutant rabies virus can be specifically targeted to cells local to an injection site, brightly labeling axons even when coexpressing two other transgenes, and several novel capabilities are demonstrated.
Journal ArticleDOI
Rabies viral vectors for monosynaptic tracing and targeted transgene expression in neurons.
TL;DR: A protocol for producing high-quality viral stocks that can be concentrated by ultracentrifugation for final titers in excess of 10(10) infectious units per milliliter is presented.
Journal ArticleDOI
Targeting thalamic circuits rescues motor and mood deficits in PD mice
Ying Zhang,Dheeraj S. Roy,Yi Zhu,Yefei Chen,Tomomi Aida,Yuanyuan Hou,Chen-Jie Shen,Nicholas Lea,Margaret E. Schroeder,Keith Skaggs,Heather A. Sullivan,Kyle B Fischer,Edward M. Callaway,Ian R. Wickersham,Ji Dai,Xiao-Ming Li,Zhonghua Lu,Guoping Feng +17 more
TL;DR: The authors found that distinct parafascicular (PF) thalamic subpopulations project to caudate putamen (CPu), subthalamic nucleus (STN), and nucleus accumbens (NAc), respectively.