Daniel Hirschstein

TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.

TL;DR: A combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct regions of the mouse cortex is established and correspondence between excitatory transcriptomic types and their region-specific long-range target specificity is demonstrated.

TL;DR: The cell type atlas for the whole adult mouse brain was created based on the combination of two singlecell-level, whole-brain-scale datasets: a single-cell RNA-sequencing (scRNA-seq) dataset of ∼7 million cells profiled, and a spatially resolved transcriptomic dataset with ∼4.3 million cells using MERFISH as discussed by the authors .

TL;DR: In this article , the authors comprehensively examined human brain cell epigenomes by probing DNA methylation and chromatin conformation at single-cell resolution in over 500,000 cells from 46 brain regions.

TL;DR: In this article , the authors harnessed single cell and spatial genomics tools and knowledge from the BRAIN Initiative Cell Census Network to understand the impact of disease progression on middle temporal gyrus cell types.