M
Michael Tieu
Researcher at Allen Institute for Brain Science
Publications - 33
Citations - 4872
Michael Tieu is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Cell type & Neocortex. The author has an hindex of 15, co-authored 24 publications receiving 2258 citations.
Papers
More filters
Journal ArticleDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Lucas T. Graybuck,Kimberly A. Smith,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Sheana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Heather A. Sullivan,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +48 more
TL;DR: This study establishes a combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct areas of the adult mouse cortex and identifies 133 transcriptomic types of glutamatergic neurons to their long-range projection specificity.
Journal ArticleDOI
Conserved cell types with divergent features in human versus mouse cortex.
Rebecca D. Hodge,Trygve E. Bakken,Jeremy A. Miller,Kimberly A. Smith,Eliza Barkan,Lucas T. Graybuck,Jennie L. Close,Brian Long,Nelson Johansen,Osnat Penn,Zizhen Yao,Jeroen Eggermont,Thomas Höllt,Thomas Höllt,Boaz P. Levi,Soraya I. Shehata,Brian D. Aevermann,Allison Beller,Darren Bertagnolli,Krissy Brouner,Tamara Casper,Charles Cobbs,Rachel A. Dalley,Nick Dee,Songlin Ding,Richard G. Ellenbogen,Olivia Fong,Emma Garren,Jeff Goldy,Ryder P. Gwinn,Daniel Hirschstein,C. Dirk Keene,Mohamed Keshk,Andrew L. Ko,Andrew L. Ko,Kanan Lathia,Ahmed Mahfouz,Ahmed Mahfouz,Zoe Maltzer,Medea McGraw,Thuc Nghi Nguyen,Julie Nyhus,Jeffrey G. Ojemann,Jeffrey G. Ojemann,Aaron Oldre,Sheana Parry,Shannon Reynolds,Christine Rimorin,Nadiya V. Shapovalova,Saroja Somasundaram,Aaron Szafer,Elliot R. Thomsen,Michael Tieu,Gerald Quon,Richard H. Scheuermann,Richard H. Scheuermann,Rafael Yuste,Susan M. Sunkin,Boudewijn P. F. Lelieveldt,Boudewijn P. F. Lelieveldt,David Feng,Lydia Ng,Amy Bernard,Michael Hawrylycz,John W. Phillips,Bosiljka Tasic,Hongkui Zeng,Allan R. Jones,Christof Koch,Ed Lein +69 more
TL;DR: RNA-sequencing analysis of cells in the human cortex enabled identification of diverse cell types, revealing well-conserved architecture and homologous cell types as well as extensive differences when compared with datasets covering the analogous region of the mouse brain.
Posted ContentDOI
Shared and distinct transcriptomic cell types across neocortical areas
Bosiljka Tasic,Zizhen Yao,Kimberly A. Smith,Lucas T. Graybuck,Thuc Nghi Nguyen,Darren Bertagnolli,Jeff Goldy,Emma Garren,Michael N. Economo,Sarada Viswanathan,Osnat Penn,Trygve E. Bakken,Vilas Menon,Jeremy A. Miller,Olivia Fong,Karla E. Hirokawa,Kanan Lathia,Christine Rimorin,Michael Tieu,Rachael Larsen,Tamara Casper,Eliza Barkan,Matthew Kroll,Seana Parry,Nadiya V. Shapovalova,Daniel Hirschstein,Julie Pendergraft,Tae Kyung Kim,Aaron Szafer,Nick Dee,Peter A. Groblewski,Ian R. Wickersham,Ali Cetin,Julie A. Harris,Boaz P. Levi,Susan M. Sunkin,Linda Madisen,Tanya L. Daigle,Loren L. Looger,Amy Bernard,John W. Phillips,Ed S. Lein,Michael Hawrylycz,Karel Svoboda,Allan R. Jones,Christof Koch,Hongkui Zeng +46 more
TL;DR: A combined transcriptomic and projectional taxonomy of cortical cell types from functionally distinct regions of the mouse cortex is established and correspondence between excitatory transcriptomic types and their region-specific long-range target specificity is demonstrated.
Journal ArticleDOI
Single-nucleus and single-cell transcriptomes compared in matched cortical cell types.
Trygve E. Bakken,Rebecca D. Hodge,Jeremy A. Miller,Zizhen Yao,Thuc Nghi Nguyen,Brian D. Aevermann,Eliza Barkan,Darren Bertagnolli,Tamara Casper,Nick Dee,Emma Garren,Jeff Goldy,Lucas T. Graybuck,Matthew Kroll,Roger S. Lasken,Kanan Lathia,Sheana Parry,Christine Rimorin,Richard H. Scheuermann,Nicholas J. Schork,Soraya I. Shehata,Michael Tieu,John W. Phillips,Amy Bernard,Kimberly A. Smith,Hongkui Zeng,Ed Lein,Bosiljka Tasic +27 more
TL;DR: It is demonstrated that closely related neuronal cell types can be similarly discriminated with both methods if intronic sequences are included in snRNA-seq analysis, and the high information content of nuclear RNA for characterization of cellular diversity in brain tissues is illustrated.
Journal ArticleDOI
A taxonomy of transcriptomic cell types across the isocortex and hippocampal formation.
Zizhen Yao,Cindy T. J. van Velthoven,Thuc Nghi Nguyen,Jeff Goldy,Adriana E. Sedeno-Cortes,Fahimeh Baftizadeh,Darren Bertagnolli,Tamara Casper,Megan Chiang,Kirsten Crichton,Songlin Ding,Olivia Fong,Emma Garren,Alexandra Glandon,Nathan W. Gouwens,James Gray,Lucas T. Graybuck,Michael Hawrylycz,Daniel Hirschstein,Matthew Kroll,Kanan Lathia,Changkyu Lee,Boaz P. Levi,Delissa McMillen,Stephanie Mok,Thanh Pham,Qingzhong Ren,Christine Rimorin,Nadiya V. Shapovalova,Josef Sulc,Susan M. Sunkin,Michael Tieu,Amy Torkelson,Herman Tung,Katelyn Ward,Nick Dee,Kimberly A. Smith,Bosiljka Tasic,Hongkui Zeng +38 more
TL;DR: The isocortex and hippocampal formation (HPF) in the mammalian brain play critical roles in perception, cognition, emotion, and learning as discussed by the authors, and a transcriptomic cell type taxonomy revealing a comprehensive repertoire of glutamatergic and GABAergic neuron types.