H
Heikyung Suh
Researcher at Massachusetts Institute of Technology
Publications - 41
Citations - 6498
Heikyung Suh is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Gene rearrangement & Antibody. The author has an hindex of 29, co-authored 36 publications receiving 6191 citations. Previous affiliations of Heikyung Suh include Columbia University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
Craig H. Bassing,Katrin F. Chua,JoAnn Sekiguchi,Heikyung Suh,Scott Whitlow,James Fleming,Brianna C. Monroe,David N. Ciccone,Catherine T. Yan,Katerina Vlasakova,David M. Livingston,David O. Ferguson,Ralph Scully,Frederick W. Alt +13 more
TL;DR: It is shown that H2AX function is essential for mammalian DNA repair and genomic stability, and not required for NHEJ per se.
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Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
James J. Moon,Heikyung Suh,Heikyung Suh,Anna Bershteyn,Matthias Stephan,Haipeng Liu,Bonnie Huang,Mashaal Sohail,Samantha S. Luo,Soong Ho Um,Htet A. Khant,Jessica T. Goodwin,Jenelyn Ramos,Wah Chiu,Darrell J. Irvine +14 more
TL;DR: In this article, the authors describe interbilayer-crosslinked multilamellar vesicles formed by crosslinking headgroups of adjacent lipid bilayers within multilevel-vesicles, which can elicit endogenous T-cell and antibody responses comparable to those for the strongest vaccine vectors.
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Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors.
Craig H. Bassing,Heikyung Suh,David O. Ferguson,David O. Ferguson,Katrin F. Chua,John P. Manis,Mark Eckersdorff,Megan Gleason,Rodrick Bronson,Charles Lee,Frederick W. Alt +10 more
TL;DR: H2AX functions as a dosage-dependent suppressor of genomic instability and tumors in mice and maps to a cytogenetic region frequently altered in human cancers, possibly implicating similar functions in man.
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Content and organization of the human Ig VH locus: definition of three new VH families and linkage to the Ig CH locus.
Jeffrey E. Berman,S. J. Mellis,Roberta R. Pollock,Cassandra L. Smith,Heikyung Suh,B. Heinke,C. Kowal,Urvashi Surti,Leonard Chess,C. R. Cantor +9 more
TL;DR: The first report of the physical linkage of the variable and constant loci of a human Ig gene family is provided by demonstrating that the most proximal known human VH segments lie within 100 kb of the constant region locus.
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Introduced T cell receptor variable region gene segments recombine in pre-B cells: Evidence that B and T cells use a common recombinase
TL;DR: The introduced TCR gene segments join very frequently and closely resemble introduced Ig gene segments in their recombination characteristics, suggesting a new role for conventional Ig transcriptional enhancers--recombinational enhancement.