Helen Yu

TL;DR: It is shown that BAP1 is recruited to double-strand DNA break sites and promotes error-free repair of these lesions, providing the first evidence that phosphorylation coordinates the function of B AP1 in promoting cellular recovery from DNA damage.

TL;DR: The findings establish a direct link between BAP1 and the transcriptional control of genes regulating cell growth and proliferation and shed light on a novel mechanism of transcription regulation involving ubiquitin signaling.

TL;DR: Using CRISPR-Cas9 approaches in patient-derived GBM stem cells to interrogate function of the coding genome, actionable pathways responsible for growth are identified, which reveal the gene-essential circuitry of G BM stemness and proliferation.

TL;DR: BAP1 forms two mutually exclusive complexes with the transcriptional regulators ASXL1 and ASXL2, which are necessary for maintaining proper protein levels of this DUB, and it is demonstrated that BAP1 interaction with AsXL2 regulates cell senescence and that AS XL2 cancer-associated mutations disrupt B AP1 DUB activity.

TL;DR: This review summarizes current findings on the critical functions exerted by E3s and DUBs in transcriptional control, particularly chromatin remodeling and transcription initiation/elongation.