H
Helena J. Mauceri
Researcher at University of Chicago
Publications - 67
Citations - 6710
Helena J. Mauceri is an academic researcher from University of Chicago. The author has contributed to research in topics: Radiation therapy & Genetic enhancement. The author has an hindex of 32, co-authored 67 publications receiving 5902 citations. Previous affiliations of Helena J. Mauceri include Harvard University.
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Journal ArticleDOI
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Liufu Deng,Hua Liang,Meng Xu,Xuanming Yang,Byron Burnette,Ainhoa Arina,Xiao Dong Li,Helena J. Mauceri,Michael A. Beckett,Thomas E. Darga,Xiaona Huang,Thomas F. Gajewski,Zhijian J. Chen,Yang Xin Fu,Ralph R. Weichselbaum +14 more
TL;DR: Radiation-mediated antitumor immunity in immunogenic tumors requires a functional cytosolic DNA-sensing pathway and suggests that cGAMP treatment might provide a new strategy to improve radiotherapy.
Journal Article
Blockade of the Vascular Endothelial Growth Factor Stress Response Increases the Antitumor Effects of Ionizing Radiation
David H. Gorski,Michael A. Beckett,Nora Jaskowiak,Douglas P. Calvin,Helena J. Mauceri,Rabih M. Salloum,Saraswathy Seetharam,Ann Koons,Danielle M. Hari,Donald Kufe,Ralph R. Weichselbaum +10 more
TL;DR: It is reported that VEGF expression is induced in Lewis lung carcinomas (LLCs) both in vitro and in vivo after exposure to ionizing radiation (IR) and in human tumor cell lines (Seg-1 esophageal adenocarcinoma, SQ20B squamous cell carcinoma, T98 and U87 glioblastomas, and U1 melanoma) in vitro.
Journal ArticleDOI
Combined effects of angiostatin and ionizing radiation in antitumour therapy
Helena J. Mauceri,Nader Hanna,Michael A. Beckett,David H. Gorski,M J Staba,Kerri Anne Stellato,Kevin Bigelow,Ruth Heimann,Stephen T. Gately,Mohanraj Dhanabal,Gerald A. Soff,Vikas P. Sukhatme,Donald Kufe,Ralph R. Weichselbaum +13 more
TL;DR: The results show an antitumour interaction between ionizing radiation and angiostatin for four distinct tumour types, at doses of radiation that are used in radiotherapy.
Journal ArticleDOI
Spatial and temporal control of gene therapy using ionizing radiation.
Dennis E. Hallahan,Helena J. Mauceri,Lisa P. Seung,Edward Dunphy,Jeffrey D. Wayne,Nader Hanna,Alicia Y. Toledano,Samuel Hellman,Donald Kufe,Ralph R. Weichselbaum +9 more
TL;DR: Control of gene transcription by iohizing radiation in vivo represents a novel method of spatial and temporal regulation of gene-based medical treatments.
Journal ArticleDOI
Host STING-dependent MDSC mobilization drives extrinsic radiation resistance
Hua Liang,Liufu Deng,Yuzhu Hou,Xiangjiao Meng,Xiangjiao Meng,Xiaona Huang,Enyu Rao,Wenxin Zheng,Helena J. Mauceri,Matthias Mack,Meng Xu,Yang Xin Fu,Ralph R. Weichselbaum +12 more
TL;DR: It is proposed that radiation-induced STING activation is immunosuppressive due to (monocytic) M-MDSC infiltration, which results in tumor radioresistance and can be abrogated in humans by a translational strategy involving anti-CCR2 antibody treatment to improve radiotherapy.