Yuzhu Hou

TL;DR: It is proposed that radiation-induced STING activation is immunosuppressive due to (monocytic) M-MDSC infiltration, which results in tumor radioresistance and can be abrogated in humans by a translational strategy involving anti-CCR2 antibody treatment to improve radiotherapy.

TL;DR: It is shown that tuberous sclerosis complex 1 (TSC1) is a critical regulator of M1 and M2 phenotypes of macrophages and a key role for TSC1 in orchestrating macrophage polarization via mTOR-dependent and independent pathways.

TL;DR: It is shown that unlike circulating lymphocytes, tumor-infiltrating T cells survive therapeutic doses of irradiation, remaining functional and contributing to radiotherapy induced anti-tumor immunity.

TL;DR: It is demonstrated that inhibiting the canonical NF‐&kgr;B pathway dampened the therapeutic effect of ionizing radiation (IR), whereas non‐canonical NF-B deficiency promoted IR‐induced anti‐tumor immunity.

TL;DR: A unique pathogenic macrophage subpopulation driven by IL-23 with a distinct gene expression profile including defined types of cytokines is identified, significantly promote the dermatitis pathogenesis in a psoriasis-like mouse model and may help understand the contribution of macrophages subpopulation in Th17-cytokines-related pathogenesis.