H
Hélène Ruffieux
Researcher at University of Cambridge
Publications - 20
Citations - 1370
Hélène Ruffieux is an academic researcher from University of Cambridge. The author has contributed to research in topics: Quantitative trait locus & Immune system. The author has an hindex of 6, co-authored 17 publications receiving 1152 citations. Previous affiliations of Hélène Ruffieux include École Polytechnique Fédérale de Lausanne & Nestlé.
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Journal ArticleDOI
Genome-wide gene-based analyses of weight loss interventions identify a potential role for NKX6.3 in metabolism.
Armand Valsesia,Qiao-Ping Wang,Qiao-Ping Wang,Nele Gheldof,Jérôme Carayol,Hélène Ruffieux,Hélène Ruffieux,Teleri Clark,Victoria Shenton,Lisa J. Oyston,Gregory Lefebvre,Sylviane Metairon,Christian Chabert,Ondine Walter,Polina Mironova,Paulina Lau,Patrick Descombes,Nathalie Viguerie,Dominique Langin,Dominique Langin,Mary-Ellen Harper,Arne Astrup,Wim H. M. Saris,Robert Dent,G. Gregory Neely,Joerg Hager +25 more
TL;DR: Two loci close to NKX6.3/MIR486 and RBSG4 are identified in the Canadian discovery cohort and replicated in the DiOGenes cohort and taken forward for Bayesian fine-mapping and functional assessment in flies.
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Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.
Laura Bergamaschi,Federica Mescia,Lorinda Turner,Aimee Hanson,Prasanti Kotagiri,Benjamin J. Dunmore,Hélène Ruffieux,Aloka De Sa,Oisin Huhn,Michael D Morgan,Pehuen Pereyra Gerber,Mark R. Wills,Stephen Baker,Fernando J Calero-Nieto,Rainer Doffinger,Gordon Dougan,Anne Elmer,Ian Goodfellow,Ravindra K. Gupta,Myra Hosmillo,Kelvin Hunter,Nathalie Kingston,Paul J. Lehner,Nicholas J Matheson,Nicholas J Matheson,Jeremy K. Nicholson,Anna M. Petrunkina,Sylvia Richardson,Caroline Saunders,James Thaventhiran,Erik J.M. Toonen,Michael P. Weekes,Berthold Göttgens,Mark Toshner,Christoph Hess,John Bradley,Paul A. Lyons,Kenneth G. C. Smith +37 more
TL;DR: Using immunophenotyping, RNA sequencing, and serum cytokine analysis, this article analyzed serial samples from 207 SARS-CoV2-infected individuals with a range of disease severities over 12 weeks from symptom onset.
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Immune checkpoint blockade sensitivity and progression-free survival associates with baseline CD8+ T cell clone size and cytotoxicity
Robert A. Watson,Robert A. Watson,Orion Tong,Rosalin Cooper,Chelsea A Taylor,Piyush Kumar Sharma,Alba Verge de los Aires,E Mahe,Hélène Ruffieux,Isar Nassiri,Mark R. Middleton,Mark R. Middleton,Benjamin P. Fairfax,Benjamin P. Fairfax +13 more
TL;DR: The antitumor action of immune checkpoint blockade (ICB) is primarily mediated by CD8+ T cells as mentioned in this paper, and sensitivity to ICB varies across different cell subsets and clonotypes.
Journal ArticleDOI
Efficient inference for genetic association studies with multiple outcomes
TL;DR: This work proposes a variational inference approach which produces posterior information very close to that of MCMC inference, at a much reduced computational cost, and outperforms popular variable selection methods and tailored Bayesian procedures.
Journal ArticleDOI
A fully joint Bayesian quantitative trait locus mapping of human protein abundance in plasma.
Hélène Ruffieux,Hélène Ruffieux,Jérôme Carayol,Radu Popescu,Mary-Ellen Harper,Robert Dent,Wim H. M. Saris,Arne Astrup,Jörg Hager,Anthony C. Davison,Armand Valsesia +10 more
TL;DR: The analysis of extensive clinical data from the two cohorts indicates that the genetically-driven proteins identified by LOCUS are enriched in associations with low-grade inflammation, insulin resistance and dyslipidemia and might therefore act as endophenotypes for metabolic diseases.